Stability of metal-glutathione complexes during oxidation by hydrogen peroxide and Cu(II)-catalysis.

Published

Journal Article

Thiol-containing ligands such as glutathione (GSH) are expected to degrade in the presence of oxygen; however, complexation by Hg, Ag, and other trace metals may protect free thiol functional groups (R-S-) from oxidation, leading to persistence in surface water environments. In this study, the stability of GSH complexes with Hg2+, Ag+, and other metals including Cd2+, Zn2+, and Pb2+ was assessed during exposure to two potential environmental oxidants: H202 and Cu2+. The results indicated that Hg-(GSH)2 and Ag(GSH) complexes were completely stable for at least 2 days in the presence of either H202 or Cu2+. In contrast, free GSH oxidized within minutes to hours. Complexation by Cd, Zn, and Pb slightly decreased or did not significantly affect the oxidation rate of GSH, depending upon the pH (tested between pH 6 and 9). Thermodynamic modeling of GSH speciation demonstrated that the observed oxidation rates were not consistent with predicted free GSH3- concentration. These results indicated that Cd-, Zn-, and Pb-GSH complexes were susceptible to oxidation by a mechanism that differs from GSH3- oxidation. In contrast, Hg- and Ag-GSH complexes were inert for days, suggesting that they are stable for relatively long periods in the oxic water column. These results demonstrate that coordination of Hg(II) and Ag(I) to thiol-containing ligands can potentially increase persistence and transport in surface waters.

Full Text

Duke Authors

Cited Authors

  • Hsu-Kim, H

Published Date

  • April 2007

Published In

Volume / Issue

  • 41 / 7

Start / End Page

  • 2338 - 2342

PubMed ID

  • 17438784

Pubmed Central ID

  • 17438784

Electronic International Standard Serial Number (EISSN)

  • 1520-5851

International Standard Serial Number (ISSN)

  • 0013-936X

Digital Object Identifier (DOI)

  • 10.1021/es062269+

Language

  • eng