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Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings.

Publication ,  Journal Article
Bourque, JM; Velazquez, EJ; Tuttle, RH; Shaw, LK; O'Connor, CM; Borges-Neto, S
Published in: J Nucl Cardiol
April 2007

BACKGROUND: Left ventricular ejection fraction (LVEF) is a significant predictor of morbidity and death. The nuclear summed rest score (SRS) measures myocardial perfusion defects and provides prognostic information, but its effects on long-term outcomes are not fully established. Moreover, information regarding the potential interaction between these 2 covariates is limited. The purpose of this study was to determine whether the mortality risk associated with LVEF is the same across all values of SRS in a population undergoing evaluation for ischemic heart disease. METHODS AND RESULTS: We examined 3,187 patients who underwent cardiac catheterization and perfusion single photon emission computed tomography imaging with a maximum follow-up of 8.1 years and median follow-up of 3.1 years. Cox proportional hazards modeling showed that increasing nuclear SRS and decreasing LVEF were independently associated with a higher long-term mortality rate, with a clinically significant interaction between them (P = .032). Patients with a normal LVEF and a high SRS (greater perfusion abnormality) have a prognosis similar to those with a reduced LVEF. CONCLUSIONS: Resting perfusion studies provide prognostic information for long-term survival and significantly impact the interpretation of mortality risk associated with changes in LVEF. Patient prognostication, risk stratification, and future research using these variables should take this interaction into account.

Duke Scholars

Published In

J Nucl Cardiol

DOI

EISSN

1532-6551

Publication Date

April 2007

Volume

14

Issue

2

Start / End Page

165 / 173

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Survival Rate
  • Survival Analysis
  • Stroke Volume
  • Statistics as Topic
  • Risk Factors
  • Risk Assessment
  • Radionuclide Imaging
  • Perfusion
  • North Carolina
 

Citation

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Bourque, J. M., Velazquez, E. J., Tuttle, R. H., Shaw, L. K., O’Connor, C. M., & Borges-Neto, S. (2007). Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings. J Nucl Cardiol, 14(2), 165–173. https://doi.org/10.1016/j.nuclcard.2006.11.011
Bourque, Jamieson M., Eric J. Velazquez, Robert H. Tuttle, Linda K. Shaw, Christopher M. O’Connor, and Salvador Borges-Neto. “Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings.J Nucl Cardiol 14, no. 2 (April 2007): 165–73. https://doi.org/10.1016/j.nuclcard.2006.11.011.
Bourque JM, Velazquez EJ, Tuttle RH, Shaw LK, O’Connor CM, Borges-Neto S. Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings. J Nucl Cardiol. 2007 Apr;14(2):165–73.
Bourque, Jamieson M., et al. “Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings.J Nucl Cardiol, vol. 14, no. 2, Apr. 2007, pp. 165–73. Pubmed, doi:10.1016/j.nuclcard.2006.11.011.
Bourque JM, Velazquez EJ, Tuttle RH, Shaw LK, O’Connor CM, Borges-Neto S. Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings. J Nucl Cardiol. 2007 Apr;14(2):165–173.
Journal cover image

Published In

J Nucl Cardiol

DOI

EISSN

1532-6551

Publication Date

April 2007

Volume

14

Issue

2

Start / End Page

165 / 173

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Survival Rate
  • Survival Analysis
  • Stroke Volume
  • Statistics as Topic
  • Risk Factors
  • Risk Assessment
  • Radionuclide Imaging
  • Perfusion
  • North Carolina