Skip to main content
Journal cover image

Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge.

Publication ,  Journal Article
Davis, CJ; Gurbel, PA; Gattis, WA; Fuzaylov, SY; Nair, GV; O'Connor, CM; Serebruany, VL
Published in: Int J Cardiol
August 2000

Knowledge of the pathogenesis of congestive heart failure (CHF) has improved greatly in recent years. However, this disease continues to cause one of the highest morbidities and mortalities in the Western world. The pathophysiology of heart failure is complex and much of our understanding revolves strictly around the neurohormonal mechanisms involved. Various pharmacologic interventions have significantly improved morbidity and include ACE inhibitors, beta-blockers, diuretics, and inotropic agents. Yet, no consensus has been reached regarding the use of anticoagulants or antiplatelet agents. It has been suggested that CHF is associated with altered hemostasis, but whether this prothrombotic state contributes to the pathogenesis and progression of the disease is unknown. The purpose of this review article is to discuss our current knowledge of platelet activation, thrombin generation, fibrinolysis, and endothelial dysfunction in CHF patients, and the potential role of anticoagulants and/or antiplatelet agents in preventing these hemostatic abnormalities.

Duke Scholars

Published In

Int J Cardiol

DOI

ISSN

0167-5273

Publication Date

August 2000

Volume

75

Issue

1

Start / End Page

15 / 21

Location

Netherlands

Related Subject Headings

  • Warfarin
  • Thromboembolism
  • Thrombin
  • Retrospective Studies
  • Platelet Aggregation Inhibitors
  • Platelet Activation
  • Humans
  • Hemostasis
  • Heart Failure
  • Fibrinolytic Agents
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davis, C. J., Gurbel, P. A., Gattis, W. A., Fuzaylov, S. Y., Nair, G. V., O’Connor, C. M., & Serebruany, V. L. (2000). Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge. Int J Cardiol, 75(1), 15–21. https://doi.org/10.1016/s0167-5273(00)00300-4
Davis, C. J., P. A. Gurbel, W. A. Gattis, S. Y. Fuzaylov, G. V. Nair, C. M. O’Connor, and V. L. Serebruany. “Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge.Int J Cardiol 75, no. 1 (August 2000): 15–21. https://doi.org/10.1016/s0167-5273(00)00300-4.
Davis CJ, Gurbel PA, Gattis WA, Fuzaylov SY, Nair GV, O’Connor CM, et al. Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge. Int J Cardiol. 2000 Aug;75(1):15–21.
Davis, C. J., et al. “Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge.Int J Cardiol, vol. 75, no. 1, Aug. 2000, pp. 15–21. Pubmed, doi:10.1016/s0167-5273(00)00300-4.
Davis CJ, Gurbel PA, Gattis WA, Fuzaylov SY, Nair GV, O’Connor CM, Serebruany VL. Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge. Int J Cardiol. 2000 Aug;75(1):15–21.
Journal cover image

Published In

Int J Cardiol

DOI

ISSN

0167-5273

Publication Date

August 2000

Volume

75

Issue

1

Start / End Page

15 / 21

Location

Netherlands

Related Subject Headings

  • Warfarin
  • Thromboembolism
  • Thrombin
  • Retrospective Studies
  • Platelet Aggregation Inhibitors
  • Platelet Activation
  • Humans
  • Hemostasis
  • Heart Failure
  • Fibrinolytic Agents