Cardiorenal syndrome clinical trial end points.
Publication
, Journal Article
Mentz, RJ; O'Connor, CM
Published in: Heart Fail Clin
October 2011
Cardiorenal syndrome is a focus of interest in heart failure because of the substantial associated morbidity and mortality. Recent clinical trials of novel heart failure therapies targeting the interdependence of cardiac and renal dysfunction have failed to show significant benefits with respect to many end points. The heterogeneity of this patient population and the lack of standardized clinical trial end points complicate forward progress. This article reviews the end points evaluated in key clinical trials of cardiorenal syndrome and synthesizes recent discussions about the appropriateness of end points for future trials.
Duke Scholars
Published In
Heart Fail Clin
DOI
ISSN
1551-7136
Publication Date
October 2011
Volume
7
Issue
4
Start / End Page
519 / 528
Location
United States
Related Subject Headings
- Prognosis
- Humans
- Disease Progression
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Cardio-Renal Syndrome
- Biomarkers
- 3201 Cardiovascular medicine and haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Mentz, R. J., & O’Connor, C. M. (2011). Cardiorenal syndrome clinical trial end points. Heart Fail Clin, 7(4), 519–528. https://doi.org/10.1016/j.hfc.2011.06.012
Mentz, Robert J., and Christopher M. O’Connor. “Cardiorenal syndrome clinical trial end points.” Heart Fail Clin 7, no. 4 (October 2011): 519–28. https://doi.org/10.1016/j.hfc.2011.06.012.
Mentz RJ, O’Connor CM. Cardiorenal syndrome clinical trial end points. Heart Fail Clin. 2011 Oct;7(4):519–28.
Mentz, Robert J., and Christopher M. O’Connor. “Cardiorenal syndrome clinical trial end points.” Heart Fail Clin, vol. 7, no. 4, Oct. 2011, pp. 519–28. Pubmed, doi:10.1016/j.hfc.2011.06.012.
Mentz RJ, O’Connor CM. Cardiorenal syndrome clinical trial end points. Heart Fail Clin. 2011 Oct;7(4):519–528.
Published In
Heart Fail Clin
DOI
ISSN
1551-7136
Publication Date
October 2011
Volume
7
Issue
4
Start / End Page
519 / 528
Location
United States
Related Subject Headings
- Prognosis
- Humans
- Disease Progression
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Cardio-Renal Syndrome
- Biomarkers
- 3201 Cardiovascular medicine and haematology