Relation between volume of exercise and clinical outcomes in patients with heart failure.

Journal Article (Journal Article)

OBJECTIVES: This study determined whether greater volumes of exercise were associated with greater reductions in clinical events. BACKGROUND: The HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial showed that among patients with heart failure (HF), regular exercise confers a modest reduction in the adjusted risk for all-cause mortality or hospitalization. METHODS: Patients randomized to the exercise training arm of HF-ACTION who were event-free at 3 months after randomization were included (n = 959). Median follow-up was 28.2 months. Clinical endpoints were all-cause mortality or hospitalization and cardiovascular mortality or HF hospitalization. RESULTS: A reverse J-shaped association was observed between exercise volume and adjusted clinical risk. On the basis of Cox regression, exercise volume was not a significant linear predictor but was a logarithmic predictor (p = 0.03) for all-cause mortality or hospitalization. For cardiovascular mortality or HF hospitalization, exercise volume was a significant (p = 0.001) linear and logarithmic predictor. Moderate exercise volumes of 3 to <5 metabolic equivalent (MET)-h and 5 to <7 MET-h per week were associated with reductions in subsequent risk that exceeded 30%. Exercise volume was positively associated with the change in peak oxygen uptake at 3 months (r = 0.10; p = 0.005). CONCLUSIONS: In patients with chronic systolic HF, volume of exercise is associated with the risk for clinical events, with only moderate levels (3 to 7 MET-h per week) of exercise needed to observe a clinical benefit. Although further study is warranted to confirm the relationship between volume of exercise completed and clinical events, our findings support the use of regular exercise in the management of these patients.

Full Text

Duke Authors

Cited Authors

  • Keteyian, SJ; Leifer, ES; Houston-Miller, N; Kraus, WE; Brawner, CA; O'Connor, CM; Whellan, DJ; Cooper, LS; Fleg, JL; Kitzman, DW; Cohen-Solal, A; Blumenthal, JA; Rendall, DS; Piña, IL; HF-ACTION Investigators,

Published Date

  • November 6, 2012

Published In

Volume / Issue

  • 60 / 19

Start / End Page

  • 1899 - 1905

PubMed ID

  • 23062530

Pubmed Central ID

  • PMC3804919

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2012.08.958


  • eng

Conference Location

  • United States