Overview of current noninodilator therapies for acute heart failure syndromes.


Journal Article (Review)

Several treatment strategies exist for patients hospitalized with acute heart failure syndromes (AHFS). These therapies traditionally focus on improving hemodynamics and relieving congestion. This review focuses on noninodilator therapies, including diuretics, nitrovasodilators (nitroprusside and nitroglycerin), vasodilators (nesiritide), digoxin, and intravenous angiotensin-converting enzyme inhibitors. These agents are used based on their associated symptomatic improvements alone. In the hospitalized setting, none of these agents have demonstrated benefits on long-term outcomes. Future work in AHFS should strive to understand the influence of conventional and new pharmacologic therapies on the underlying pathophysiology of AHFS, the processes that lead to myocardial injury and progressive heart failure, and measurable clinical outcomes.

Full Text

Duke Authors

Cited Authors

  • Stough, WG; O'Connor, CM; Gheorghiade, M

Published Date

  • September 19, 2005

Published In

Volume / Issue

  • 96 / 6A

Start / End Page

  • 41G - 46G

PubMed ID

  • 16181822

Pubmed Central ID

  • 16181822

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2005.07.020


  • eng

Conference Location

  • United States