CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction.
Journal Article
Computed tomographic (CT) patterns of intracranial hemorrhage (ICH) were determined in 1,696 patients undergoing thrombolytic therapy for acute myocardial infarction. ICH occurred at 33 sites in 0.77% of patients (n = 13). Thirty-six percent of hemorrhages (n = 12) were intraparenchymal, 33% (n = 11) were subdural, 24% (n = 8) were subarachnoid, and 6% (n = 2) were intraventricular. Eight-four percent (n = 26) of all nonventricular hemorrhages were supratentorial in location. The most common site of ICH was supratentorial and intraparenchymal (10 of 33). In 11 of the 13 patients with ICH, clinical symptoms occurred within 24 hours of the initiation of thrombolytic therapy. A fatal outcome resulted in three of the four patients who had clinical symptoms within 3.5 hours after beginning thrombolytic therapy. The CT findings of multiple intracranial bleeding sites, substantial mass effect with midline shift, and large-volume intraparenchymal hematomas were associated with increased mortality. ICH associated with thrombolytic therapy for acute myocardial infarction has a grave prognosis, with 62% of patients dying during hospitalization.
Full Text
Duke Authors
Cited Authors
- Uglietta, JP; O'Connor, CM; Boyko, OB; Aldrich, H; Massey, EW; Heinz, ER
Published Date
- November 1991
Published In
Volume / Issue
- 181 / 2
Start / End Page
- 555 - 559
PubMed ID
- 1924804
Pubmed Central ID
- 1924804
International Standard Serial Number (ISSN)
- 0033-8419
Digital Object Identifier (DOI)
- 10.1148/radiology.181.2.1924804
Language
- eng
Conference Location
- United States