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Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study.

Publication ,  Journal Article
Cabell, CH; Trichon, BH; Velazquez, EJ; Dumesnil, JG; Anstrom, KJ; Ryan, T; Miller, AB; Belkin, RN; Cropp, AB; O'Connor, CM; Jollis, JG
Published in: Am Heart J
January 2004

BACKGROUND: Echocardiography is used commonly in clinical practice when caring for patients with heart failure. It is unknown whether the presence of certain findings provides an incremental ability to predict survival beyond the use of baseline clinical findings alone. The second PRAISE-2 echocardiographic study was prospectively designed to identify echocardiographic predictors of survival among patients with nonischemic cardiomyopathy and heart failure and to determine if components of the echocardiographic examination add prognostic information to baseline demographic and clinical information. METHODS: One hundred patients participated in the second Prospective Randomized Amlodipine Survival Evaluation Study (PRAISE-2) echocardiographic study; of these, 93 had full and interpretable echocardiographic examinations. Cox proportional hazards modeling was used to assess the relation between various characteristics and survival as well as to assess the incremental prognostic information gained by echocardiography beyond the clinical examination. RESULTS: Seven of 10 routine echocardiographic measures were significantly associated with death. These included mitral regurgitation (hazard ratio [HR], 2.31; 95% CI, 1.02, 5.27), left ventricular ejection fraction <20% (HR, 2.59; 95% CI, 1.14, 5.88), restrictive left ventricular filling pattern (HR, 2.37; 95% CI, 1.05, 5.32), and peak D velocity (HR, 1.62; 95% CI, 0.38, 0.87). The only statistically significant clinical predictor of survival was dyspnea at rest. The addition any of several echocardiographic parameters to baseline clinical information significantly improved the ability to predict survival. CONCLUSIONS: Several readily available echocardiographic parameters are predictive of death and when added to clinical examination findings significantly improve the ability to determine prognosis among patients with nonischemic cardiomyopathy and heart failure.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2004

Volume

147

Issue

1

Start / End Page

151 / 157

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Survival Analysis
  • Stroke Volume
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Patient Selection
  • Mitral Valve Insufficiency
  • Middle Aged
  • Male
 

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Cabell, C. H., Trichon, B. H., Velazquez, E. J., Dumesnil, J. G., Anstrom, K. J., Ryan, T., … Jollis, J. G. (2004). Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study. Am Heart J, 147(1), 151–157. https://doi.org/10.1016/j.ahj.2003.07.010
Cabell, Christopher H., Benjamin H. Trichon, Eric J. Velazquez, Jean G. Dumesnil, Kevin J. Anstrom, Thomas Ryan, Alan B. Miller, et al. “Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study.Am Heart J 147, no. 1 (January 2004): 151–57. https://doi.org/10.1016/j.ahj.2003.07.010.
Cabell, Christopher H., et al. “Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study.Am Heart J, vol. 147, no. 1, Jan. 2004, pp. 151–57. Pubmed, doi:10.1016/j.ahj.2003.07.010.
Cabell CH, Trichon BH, Velazquez EJ, Dumesnil JG, Anstrom KJ, Ryan T, Miller AB, Belkin RN, Cropp AB, O’Connor CM, Jollis JG. Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study. Am Heart J. 2004 Jan;147(1):151–157.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2004

Volume

147

Issue

1

Start / End Page

151 / 157

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Survival Analysis
  • Stroke Volume
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Patient Selection
  • Mitral Valve Insufficiency
  • Middle Aged
  • Male