Biomarker guided therapy for heart failure: focus on natriuretic peptides.

Journal Article (Journal Article;Review)

The management of heart failure remains challenging despite many therapeutic advances. Rigorous clinical trial evidence supports administration of multiple therapies, but utilization of evidence-based treatment remains inconsistent and suboptimal. Disease management programs appear effective, but remain costly and difficult to implement in today's care system. Another approach involves optimizing therapy based on serial monitoring of cardiac biomarkers. Emerging results suggest that guiding therapy based on serial changes in natriuretic peptides may be an effective strategy. Although pilot work has provided encouraging results, appropriately designed, large-scale, prospective randomized trials are needed to confirm these preliminary findings and definitively establish this therapeutic approach.

Full Text

Duke Authors

Cited Authors

  • Adams, KF; Felker, GM; Fraij, G; Patterson, JH; O'Connor, CM

Published Date

  • July 2010

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 351 - 370

PubMed ID

  • 19377882

Electronic International Standard Serial Number (EISSN)

  • 1573-7322

Digital Object Identifier (DOI)

  • 10.1007/s10741-009-9139-9


  • eng

Conference Location

  • United States