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Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function.

Publication ,  Journal Article
Ponikowski, P; Mitrovic, V; O'Connor, CM; Dittrich, H; Cotter, G; Massie, BM; Givertz, MM; Chen, E; Murray, M; Weatherley, BD; Fujita, KP; Metra, M
Published in: Eur J Heart Fail
November 2010

AIMS: The direct effects of adenosine A1 receptor antagonists on haemodynamic parameters in patients with acute heart failure (HF) remain largely unknown. METHODS AND RESULTS: We evaluated the haemodynamic effects of the AA(1)RA rolofylline in 59 HF patients with concomitant renal impairment (estimated creatinine clearance 20-80 mL/min). Placebo or rolofylline 30 mg was administered as a 4 h infusion followed by intravenous (i.v.) loop diuretic administration. Haemodynamic measurements were carried out hourly up to 8 h post-dosing by pulmonary artery catheterization. Urine output, fractional excretion of sodium, potassium, urea, and uric acid, and blood urea nitrogen (BUN) and creatinine levels were also measured. In both groups, the changes from baseline in all haemodynamic indices except mean pulmonary artery pressure (PAP) were not clinically significant. Mean [95% confidence interval (CI)] PAP showed a placebo-adjusted decrease with rolofylline of -1.5 (-4.1, 1.1)mmHg at Hour 4 and -3.5 mmHg (95% CI: -6.2, -0.2) at Hour 8. There was a significant increase with rolofylline in diuresis [placebo-corrected mean (95% CI) change of 68 (20, 116)mL/h at Hour 2-4 and 103 (21, 185)mL/h at Hour 4-8] and in fractional excretion of sodium, potassium, and uric acid. Placebo-corrected changes in plasma levels of creatinine and BUN with rolofylline were non-significant. CONCLUSION: Single administration of rolofylline in patients with HF and impaired renal function produced a slight decrease in mean PAP and consistently increased diuresis and natriuresis without compromising renal function, both before and after administration of i.v. loop diuretics.

Duke Scholars

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2010

Volume

12

Issue

11

Start / End Page

1238 / 1246

Location

England

Related Subject Headings

  • Xanthines
  • Sodium Potassium Chloride Symporter Inhibitors
  • Renal Insufficiency
  • Prospective Studies
  • Middle Aged
  • Male
  • Least-Squares Analysis
  • Kidney Function Tests
  • Humans
  • Hemodynamics
 

Citation

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Ponikowski, P., Mitrovic, V., O’Connor, C. M., Dittrich, H., Cotter, G., Massie, B. M., … Metra, M. (2010). Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function. Eur J Heart Fail, 12(11), 1238–1246. https://doi.org/10.1093/eurjhf/hfq137
Ponikowski, Piotr, Veselin Mitrovic, Christopher M. O’Connor, Howard Dittrich, Gad Cotter, Barry M. Massie, Michael M. Givertz, et al. “Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function.Eur J Heart Fail 12, no. 11 (November 2010): 1238–46. https://doi.org/10.1093/eurjhf/hfq137.
Ponikowski P, Mitrovic V, O’Connor CM, Dittrich H, Cotter G, Massie BM, et al. Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function. Eur J Heart Fail. 2010 Nov;12(11):1238–46.
Ponikowski, Piotr, et al. “Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function.Eur J Heart Fail, vol. 12, no. 11, Nov. 2010, pp. 1238–46. Pubmed, doi:10.1093/eurjhf/hfq137.
Ponikowski P, Mitrovic V, O’Connor CM, Dittrich H, Cotter G, Massie BM, Givertz MM, Chen E, Murray M, Weatherley BD, Fujita KP, Metra M. Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function. Eur J Heart Fail. 2010 Nov;12(11):1238–1246.
Journal cover image

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2010

Volume

12

Issue

11

Start / End Page

1238 / 1246

Location

England

Related Subject Headings

  • Xanthines
  • Sodium Potassium Chloride Symporter Inhibitors
  • Renal Insufficiency
  • Prospective Studies
  • Middle Aged
  • Male
  • Least-Squares Analysis
  • Kidney Function Tests
  • Humans
  • Hemodynamics