Standardizing care for acute decompensated heart failure in a large megatrial: the approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF).


Journal Article (Review)

Acute decompensated heart failure (ADHF) is a major public health issue and remains a heterogeneous, complex, and difficult condition to manage. Although novel acute therapies are being tested in large randomized clinical trials, opportunities exist to improve the standard of care by ensuring optimal adherence to currently established evidence-based interventions for HF. Consideration of the goals of therapy and practical application of current methods to assess for clinical improvement may lead to improved patient management and possibly improved outcomes for patients with ADHF. This review provides key practical information regarding the current standard of care for patients with ADHF including the goals of therapy, management of acute and chronic medications, and discharge/transition of care planning.

Full Text

Duke Authors

Cited Authors

  • Ezekowitz, JA; Hernandez, AF; Starling, RC; Yancy, CW; Massie, B; Hill, JA; Krum, H; Diaz, R; Ponikowski, P; Metra, M; Howlett, JG; Gennevois, D; O'Connor, CM; Califf, RM; Fonarow, GC

Published Date

  • February 2009

Published In

Volume / Issue

  • 157 / 2

Start / End Page

  • 219 - 228

PubMed ID

  • 19185628

Pubmed Central ID

  • 19185628

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2008.10.002


  • eng

Conference Location

  • United States