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Anemia as a risk factor and therapeutic target in heart failure.

Publication ,  Journal Article
Felker, GM; Adams, KF; Gattis, WA; O'Connor, CM
Published in: J Am Coll Cardiol
September 1, 2004

Anemia has recently been recognized as an important comorbid condition and potentially novel therapeutic target in patients with heart failure (HF). Anemia is common in HF patients, with a prevalence ranging from 4% to 55% depending on the population studied. Multiple potential mechanisms of interaction exist between anemia and the clinical syndrome of HF, including hemodilution, inflammatory activation, renal insufficiency, and malnutrition. A growing body of literature from observational databases and clinical trials suggests that anemia is an independent risk factor for adverse outcomes in patients with HF. Although preliminary data suggest that treatment of anemia may result in significant symptomatic improvement in HF, aggressive treatment of anemia may also be associated with increased risk of hypertension or thrombosis. Multiple ongoing studies will provide definitive data on the balance of risks and benefits of anemia treatment in chronic HF.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

September 1, 2004

Volume

44

Issue

5

Start / End Page

959 / 966

Location

United States

Related Subject Headings

  • Risk Factors
  • Renal Dialysis
  • Recombinant Proteins
  • Kidney Failure, Chronic
  • Humans
  • Hematocrit
  • Heart Failure
  • Heart
  • Erythropoietin
  • Comorbidity
 

Citation

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Felker, G. M., Adams, K. F., Gattis, W. A., & O’Connor, C. M. (2004). Anemia as a risk factor and therapeutic target in heart failure. J Am Coll Cardiol, 44(5), 959–966. https://doi.org/10.1016/j.jacc.2004.05.070
Felker, G Michael, Kirkwood F. Adams, Wendy A. Gattis, and Christopher M. O’Connor. “Anemia as a risk factor and therapeutic target in heart failure.J Am Coll Cardiol 44, no. 5 (September 1, 2004): 959–66. https://doi.org/10.1016/j.jacc.2004.05.070.
Felker GM, Adams KF, Gattis WA, O’Connor CM. Anemia as a risk factor and therapeutic target in heart failure. J Am Coll Cardiol. 2004 Sep 1;44(5):959–66.
Felker, G. Michael, et al. “Anemia as a risk factor and therapeutic target in heart failure.J Am Coll Cardiol, vol. 44, no. 5, Sept. 2004, pp. 959–66. Pubmed, doi:10.1016/j.jacc.2004.05.070.
Felker GM, Adams KF, Gattis WA, O’Connor CM. Anemia as a risk factor and therapeutic target in heart failure. J Am Coll Cardiol. 2004 Sep 1;44(5):959–966.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

September 1, 2004

Volume

44

Issue

5

Start / End Page

959 / 966

Location

United States

Related Subject Headings

  • Risk Factors
  • Renal Dialysis
  • Recombinant Proteins
  • Kidney Failure, Chronic
  • Humans
  • Hematocrit
  • Heart Failure
  • Heart
  • Erythropoietin
  • Comorbidity