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Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial.

Publication ,  Journal Article
Hasselblad, V; Gattis Stough, W; Shah, MR; Lokhnygina, Y; O'Connor, CM; Califf, RM; Adams, KF
Published in: Eur J Heart Fail
October 2007

BACKGROUND: We examined the relation of maximal in-hospital diuretic dose to weight loss, changes in renal function, and mortality in hospitalised heart failure (HF) patients. METHODS: In ESCAPE, 395 patients received diuretics in-hospital. Weight was measured at baseline, discharge, and every other day before discharge. Weight loss was defined as the difference between baseline and last in-hospital weight. Mortality was assessed using a log-logistic model with non-zero background. RESULTS: Median weight loss: 2.8 kg (0.7, 6.1); mean: 3.7 kg (22% of values <0). Weight loss and maximum in-hospital dose were correlated (p=0.0007). Baseline weight, length of stay, and baseline brain natriuretic peptide were significant predictors of weight loss. After adjusting for these, dose was not a significant predictor of weight loss. A strong relation between dose and mortality was seen (p=0.003), especially at >300 mg/day. Dose remained a significant predictor of mortality after adjusting for baseline variables that significantly predicted mortality. Correlation between maximal dose and creatinine level change was not significant (r=0.043; p=0.412) CONCLUSIONS: High diuretic doses during HF hospitalisation are associated with increased mortality and poor 6-month outcome.

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Published In

Eur J Heart Fail

DOI

ISSN

1388-9842

Publication Date

October 2007

Volume

9

Issue

10

Start / End Page

1064 / 1069

Location

England

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Sodium Potassium Chloride Symporter Inhibitors
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Length of Stay
  • Kidney
  • Humans
  • Hospitalization
 

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Hasselblad, V., Gattis Stough, W., Shah, M. R., Lokhnygina, Y., O’Connor, C. M., Califf, R. M., & Adams, K. F. (2007). Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. Eur J Heart Fail, 9(10), 1064–1069. https://doi.org/10.1016/j.ejheart.2007.07.011
Hasselblad, Vic, Wendy Gattis Stough, Monica R. Shah, Yuliya Lokhnygina, Christopher M. O’Connor, Robert M. Califf, and Kirkwood F. Adams. “Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial.Eur J Heart Fail 9, no. 10 (October 2007): 1064–69. https://doi.org/10.1016/j.ejheart.2007.07.011.
Hasselblad V, Gattis Stough W, Shah MR, Lokhnygina Y, O’Connor CM, Califf RM, et al. Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. Eur J Heart Fail. 2007 Oct;9(10):1064–9.
Hasselblad, Vic, et al. “Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial.Eur J Heart Fail, vol. 9, no. 10, Oct. 2007, pp. 1064–69. Pubmed, doi:10.1016/j.ejheart.2007.07.011.
Hasselblad V, Gattis Stough W, Shah MR, Lokhnygina Y, O’Connor CM, Califf RM, Adams KF. Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. Eur J Heart Fail. 2007 Oct;9(10):1064–1069.
Journal cover image

Published In

Eur J Heart Fail

DOI

ISSN

1388-9842

Publication Date

October 2007

Volume

9

Issue

10

Start / End Page

1064 / 1069

Location

England

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Sodium Potassium Chloride Symporter Inhibitors
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Length of Stay
  • Kidney
  • Humans
  • Hospitalization