On-line adaptive radiation therapy: feasibility and clinical study.

Journal Article (Journal Article)

The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer treatment based on daily cone-beam CT imaging and fast volumetric reoptimization of treatment plans. A fast intensity-modulated radiotherapy (IMRT) plan reoptimization algorithm is implemented and evaluated with clinical cases. The quality of these adapted plans is compared to the corresponding new plans generated by an experienced planner using a commercial treatment planning system and also evaluated by an in-house developed tool estimating achievable dose-volume histograms (DVHs) based on a database of existing treatment plans. In addition, a clinical implementation scheme for ART is designed and evaluated using clinical cases for its dosimetric qualities and efficiency.

Full Text

Duke Authors

Cited Authors

  • Li, T; Zhu, X; Thongphiew, D; Lee, WR; Vujaskovic, Z; Wu, Q; Yin, F-F; Wu, QJ

Published Date

  • 2010

Published In

Volume / Issue

  • 2010 /

Start / End Page

  • 407236 -

PubMed ID

  • 21113304

Pubmed Central ID

  • PMC2990023

Electronic International Standard Serial Number (EISSN)

  • 1687-8469

Digital Object Identifier (DOI)

  • 10.1155/2010/407236


  • eng

Conference Location

  • Egypt