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Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters.

Publication ,  Journal Article
Craciunescu, OI; Yoo, DS; Cleland, E; Muradyan, N; Carroll, MD; MacFall, JR; Barboriak, DP; Brizel, DM
Published in: Int J Radiat Oncol Biol Phys
March 1, 2012

PURPOSE: Dynamic contrast-enhanced (DCE) MRI-extracted parameters measure tumor microvascular physiology and are usually calculated from an intratumor region of interest (ROI). Optimal ROI delineation is not established. The valid clinical use of DCE-MRI requires that the variation for any given parameter measured within a tumor be less than that observed between tumors in different patients. This work evaluates the impact of tumor ROI selection on the assessment of intra- and interpatient variability. METHOD AND MATERIALS: Head and neck cancer patients received initial targeted therapy (TT) treatment with erlotinib and/or bevacizumab, followed by radiotherapy and concurrent cisplatin with synchronous TT. DCE-MRI data from Baseline and the end of the TT regimen (Lead-In) were analyzed to generate the vascular transfer function (K(trans)), the extracellular volume fraction (v(e)), and the initial area under the concentration time curve (iAUC(1 min)). Four ROI sampling strategies were used: whole tumor or lymph node (Whole), the slice containing the most enhancing voxels (SliceMax), three slices centered in SliceMax (Partial), and the 5% most enhancing contiguous voxels within SliceMax (95Max). The average coefficient of variation (aCV) was calculated to establish intrapatient variability among ROI sets and interpatient variability for each ROI type. The average ratio between each intrapatient CV and the interpatient CV was calculated (aRCV). RESULTS: Baseline primary/nodes aRCVs for different ROIs not including 95Max were, for all three MR parameters, in the range of 0.14-0.24, with Lead-In values between 0.09 and 0.2, meaning a low intrapatient vs. interpatient variation. For 95Max, intrapatient CVs approximated interpatient CVs, meaning similar data dispersion and higher aRCVs (0.6-1.27 for baseline) and 0.54-0.95 for Lead-In. CONCLUSION: Distinction between different patient's primary tumors and/or nodes cannot be made using 95Max ROIs. The other three strategies are viable and equivalent for using DCE-MRI to measure head and neck cancer physiology.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 1, 2012

Volume

82

Issue

3

Start / End Page

e345 / e350

Location

United States

Related Subject Headings

  • Quinazolines
  • Oncology & Carcinogenesis
  • North Carolina
  • Molecular Targeted Therapy
  • Microcirculation
  • Magnetic Resonance Imaging
  • Lymphatic Metastasis
  • Image Enhancement
  • Humans
  • Head and Neck Neoplasms
 

Citation

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Craciunescu, O. I., Yoo, D. S., Cleland, E., Muradyan, N., Carroll, M. D., MacFall, J. R., … Brizel, D. M. (2012). Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters. Int J Radiat Oncol Biol Phys, 82(3), e345–e350. https://doi.org/10.1016/j.ijrobp.2011.05.059
Craciunescu, Oana I., David S. Yoo, Esi Cleland, Naira Muradyan, Madeline D. Carroll, James R. MacFall, Daniel P. Barboriak, and David M. Brizel. “Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters.Int J Radiat Oncol Biol Phys 82, no. 3 (March 1, 2012): e345–50. https://doi.org/10.1016/j.ijrobp.2011.05.059.
Craciunescu OI, Yoo DS, Cleland E, Muradyan N, Carroll MD, MacFall JR, et al. Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters. Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):e345–50.
Craciunescu, Oana I., et al. “Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters.Int J Radiat Oncol Biol Phys, vol. 82, no. 3, Mar. 2012, pp. e345–50. Pubmed, doi:10.1016/j.ijrobp.2011.05.059.
Craciunescu OI, Yoo DS, Cleland E, Muradyan N, Carroll MD, MacFall JR, Barboriak DP, Brizel DM. Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters. Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):e345–e350.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 1, 2012

Volume

82

Issue

3

Start / End Page

e345 / e350

Location

United States

Related Subject Headings

  • Quinazolines
  • Oncology & Carcinogenesis
  • North Carolina
  • Molecular Targeted Therapy
  • Microcirculation
  • Magnetic Resonance Imaging
  • Lymphatic Metastasis
  • Image Enhancement
  • Humans
  • Head and Neck Neoplasms