Adaptive evolution: evaluating empirical support for theoretical predictions.

Journal Article (Review;Journal Article)

Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular networks. Finally, the retention of genetic variation and the efficacy of selection depend on population genetics and demographic history. Emergent high-throughput experimental methods and sequencing technologies allow us to gather more evidence and to move beyond the theory in different systems and populations. Here we review the extent to which recent evidence supports long-established theoretical principles of adaptation.

Full Text

Duke Authors

Cited Authors

  • Olson-Manning, CF; Wagner, MR; Mitchell-Olds, T

Published Date

  • December 2012

Published In

Volume / Issue

  • 13 / 12

Start / End Page

  • 867 - 877

PubMed ID

  • 23154809

Pubmed Central ID

  • PMC3748133

Electronic International Standard Serial Number (EISSN)

  • 1471-0064

International Standard Serial Number (ISSN)

  • 1471-0056

Digital Object Identifier (DOI)

  • 10.1038/nrg3322


  • eng