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Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network.

Publication ,  Journal Article
Bart, BA; Goldsmith, SR; Lee, KL; Redfield, MM; Felker, GM; O'Connor, CM; Chen, HH; Rouleau, JL; Givertz, MM; Semigran, MJ; Mann, D; Deswal, A ...
Published in: J Card Fail
March 2012

BACKGROUND: Worsening renal function is common among patients hospitalized for acute decompensated heart failure (ADHF). When this occurs, subsequent management decisions often pit the desire for effective decongestion against concerns about further worsening renal function. There are no evidence-based treatments or guidelines to assist in these difficult management decisions. Ultrafiltration is a potentially attractive alternative to loop diuretics for the management of fluid overload in patients with ADHF and worsening renal function. METHODS AND RESULTS: The National Heart, Lung, and Blood Institute Heart Failure Clinical Research Network designed a clinical trial to determine if ultrafiltration results in improved renal function and relief of congestion compared with stepped pharmacologic care when assessed 96 hours after randomization in patients with ADHF and cardiorenal syndrome. Enrollment began in June 2008. This paper describes the rationale and design of the Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARRESS-HF). CONCLUSIONS: Treating the signs and symptoms of congestion in ADHF is often complicated by worsening renal function. CARRESS-HF compares treatment strategies (ultrafiltration vs stepped pharmacologic care) for the management of worsening renal function in patients with ADHF. The results of the CARRESS-HF trial are expected to provide information and evidence as to the most appropriate approaches for treating this challenging patient population.

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Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

March 2012

Volume

18

Issue

3

Start / End Page

176 / 182

Location

United States

Related Subject Headings

  • Prospective Studies
  • Humans
  • Hemofiltration
  • Heart Failure
  • Cardiovascular System & Hematology
  • Cardio-Renal Syndrome
  • Biomedical Research
  • Acute Disease
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Bart, B. A., Goldsmith, S. R., Lee, K. L., Redfield, M. M., Felker, G. M., O’Connor, C. M., … Braunwald, E. (2012). Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network. J Card Fail, 18(3), 176–182. https://doi.org/10.1016/j.cardfail.2011.12.009
Bart, Bradley A., Steven R. Goldsmith, Kerry L. Lee, Margaret M. Redfield, G Michael Felker, Christopher M. O’Connor, Horng H. Chen, et al. “Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network.J Card Fail 18, no. 3 (March 2012): 176–82. https://doi.org/10.1016/j.cardfail.2011.12.009.
Bart BA, Goldsmith SR, Lee KL, Redfield MM, Felker GM, O’Connor CM, et al. Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network. J Card Fail. 2012 Mar;18(3):176–82.
Bart, Bradley A., et al. “Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network.J Card Fail, vol. 18, no. 3, Mar. 2012, pp. 176–82. Pubmed, doi:10.1016/j.cardfail.2011.12.009.
Bart BA, Goldsmith SR, Lee KL, Redfield MM, Felker GM, O’Connor CM, Chen HH, Rouleau JL, Givertz MM, Semigran MJ, Mann D, Deswal A, Bull DA, Lewinter MM, Braunwald E. Cardiorenal rescue study in acute decompensated heart failure: rationale and design of CARRESS-HF, for the Heart Failure Clinical Research Network. J Card Fail. 2012 Mar;18(3):176–182.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

March 2012

Volume

18

Issue

3

Start / End Page

176 / 182

Location

United States

Related Subject Headings

  • Prospective Studies
  • Humans
  • Hemofiltration
  • Heart Failure
  • Cardiovascular System & Hematology
  • Cardio-Renal Syndrome
  • Biomedical Research
  • Acute Disease
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology