Skip to main content
Journal cover image

The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition.

Publication ,  Journal Article
Pajerowska-Mukhtar, KM; Wang, W; Tada, Y; Oka, N; Tucker, CL; Fonseca, JP; Dong, X
Published in: Current biology : CB
January 2012

Induction of plant immune responses involves significant transcription reprogramming that prioritizes defense over growth-related cellular functions. Despite intensive forward genetic screens and genome-wide expression-profiling studies, a limited number of transcription factors have been found that regulate this transition.Using the endoplasmic-reticulum-resident genes required for antimicrobial protein secretion as markers, we identified a heat-shock factor-like transcription factor that specifically binds to the TL1 (GAAGAAGAA) cis element required for the induction of these genes. Surprisingly, plants lacking this TL1-binding factor, TBF1, respond normally to heat stress but are compromised in immune responses induced by salicylic acid and by microbe-associated molecular pattern, elf18. Genome-wide expression profiling indicates that TBF1 plays a key role in the growth-to-defense transition. Moreover, the expression of TBF1 itself is tightly regulated at both the transcriptional and translational levels. Two upstream open reading frames encoding multiple aromatic amino acids were found 5' of the translation initiation codon of TBF1 and shown to affect its translation.Through this unique regulatory mechanism, TBF1 can sense the metabolic changes upon pathogen invasion and trigger the specific transcriptional reprogramming through its target genes expression.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Current biology : CB

DOI

EISSN

1879-0445

ISSN

0960-9822

Publication Date

January 2012

Volume

22

Issue

2

Start / End Page

103 / 112

Related Subject Headings

  • Transcription Factors
  • Salicylic Acid
  • Promoter Regions, Genetic
  • Plant Proteins
  • Peptide Fragments
  • Peptide Elongation Factor Tu
  • Open Reading Frames
  • Immunity, Innate
  • Heat-Shock Proteins
  • Heat Shock Transcription Factors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pajerowska-Mukhtar, K. M., Wang, W., Tada, Y., Oka, N., Tucker, C. L., Fonseca, J. P., & Dong, X. (2012). The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. Current Biology : CB, 22(2), 103–112. https://doi.org/10.1016/j.cub.2011.12.015
Pajerowska-Mukhtar, Karolina M., Wei Wang, Yasuomi Tada, Nodoka Oka, Chandra L. Tucker, Jose Pedro Fonseca, and Xinnian Dong. “The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition.Current Biology : CB 22, no. 2 (January 2012): 103–12. https://doi.org/10.1016/j.cub.2011.12.015.
Pajerowska-Mukhtar KM, Wang W, Tada Y, Oka N, Tucker CL, Fonseca JP, et al. The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. Current biology : CB. 2012 Jan;22(2):103–12.
Pajerowska-Mukhtar, Karolina M., et al. “The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition.Current Biology : CB, vol. 22, no. 2, Jan. 2012, pp. 103–12. Epmc, doi:10.1016/j.cub.2011.12.015.
Pajerowska-Mukhtar KM, Wang W, Tada Y, Oka N, Tucker CL, Fonseca JP, Dong X. The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. Current biology : CB. 2012 Jan;22(2):103–112.
Journal cover image

Published In

Current biology : CB

DOI

EISSN

1879-0445

ISSN

0960-9822

Publication Date

January 2012

Volume

22

Issue

2

Start / End Page

103 / 112

Related Subject Headings

  • Transcription Factors
  • Salicylic Acid
  • Promoter Regions, Genetic
  • Plant Proteins
  • Peptide Fragments
  • Peptide Elongation Factor Tu
  • Open Reading Frames
  • Immunity, Innate
  • Heat-Shock Proteins
  • Heat Shock Transcription Factors