Acquisition of "Start" and "Stop" response thresholds in peak-interval timing is differentially sensitive to protein synthesis inhibition in the dorsal and ventral striatum.


Journal Article

Time-based decision-making in peak-interval timing procedures involves the setting of response thresholds for the initiation ("Start") and termination ("Stop") of a response sequence that is centered on a target duration. Using intracerebral infusions of the protein synthesis inhibitor anisomycin, we report that the acquisition of the "Start" response depends on normal functioning (including protein synthesis) in the dorsal striatum (DS), but not the ventral striatum (VS). Conversely, disruption of the VS, but not the DS, impairs the acquisition of the "Stop" response. We hypothesize that the dorsal and ventral regions of the striatum function as a competitive neural network that encodes the temporal boundaries marking the beginning and end of a timed response sequence.

Full Text

Cited Authors

  • Macdonald, CJ; Cheng, R-K; Meck, WH

Published Date

  • January 2012

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 10 -

PubMed ID

  • 22435054

Pubmed Central ID

  • 22435054

Electronic International Standard Serial Number (EISSN)

  • 1662-5145

International Standard Serial Number (ISSN)

  • 1662-5145

Digital Object Identifier (DOI)

  • 10.3389/fnint.2012.00010


  • eng