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Reliability of transcriptional cycles and the yeast cell-cycle oscillator.

Publication ,  Journal Article
Sevim, V; Gong, X; Socolar, JES
Published in: PLoS computational biology
July 2010

A recently published transcriptional oscillator associated with the yeast cell cycle provides clues and raises questions about the mechanisms underlying autonomous cyclic processes in cells. Unlike other biological and synthetic oscillatory networks in the literature, this one does not seem to rely on a constitutive signal or positive auto-regulation, but rather to operate through stable transmission of a pulse on a slow positive feedback loop that determines its period. We construct a continuous-time Boolean model of this network, which permits the modeling of noise through small fluctuations in the timing of events, and show that it can sustain stable oscillations. Analysis of simpler network models shows how a few building blocks can be arranged to provide stability against fluctuations. Our findings suggest that the transcriptional oscillator in yeast belongs to a new class of biological oscillators.

Duke Scholars

Published In

PLoS computational biology

DOI

EISSN

1553-7358

ISSN

1553-734X

Publication Date

July 2010

Volume

6

Issue

7

Start / End Page

e1000842

Related Subject Headings

  • Yeasts
  • Transcription, Genetic
  • Models, Statistical
  • Models, Genetic
  • Gene Regulatory Networks
  • Feedback, Physiological
  • Computational Biology
  • Cell Cycle
  • Bioinformatics
  • 08 Information and Computing Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sevim, V., Gong, X., & Socolar, J. E. S. (2010). Reliability of transcriptional cycles and the yeast cell-cycle oscillator. PLoS Computational Biology, 6(7), e1000842. https://doi.org/10.1371/journal.pcbi.1000842
Sevim, Volkan, Xinwei Gong, and Joshua E. S. Socolar. “Reliability of transcriptional cycles and the yeast cell-cycle oscillator.PLoS Computational Biology 6, no. 7 (July 2010): e1000842. https://doi.org/10.1371/journal.pcbi.1000842.
Sevim V, Gong X, Socolar JES. Reliability of transcriptional cycles and the yeast cell-cycle oscillator. PLoS computational biology. 2010 Jul;6(7):e1000842.
Sevim, Volkan, et al. “Reliability of transcriptional cycles and the yeast cell-cycle oscillator.PLoS Computational Biology, vol. 6, no. 7, July 2010, p. e1000842. Epmc, doi:10.1371/journal.pcbi.1000842.
Sevim V, Gong X, Socolar JES. Reliability of transcriptional cycles and the yeast cell-cycle oscillator. PLoS computational biology. 2010 Jul;6(7):e1000842.

Published In

PLoS computational biology

DOI

EISSN

1553-7358

ISSN

1553-734X

Publication Date

July 2010

Volume

6

Issue

7

Start / End Page

e1000842

Related Subject Headings

  • Yeasts
  • Transcription, Genetic
  • Models, Statistical
  • Models, Genetic
  • Gene Regulatory Networks
  • Feedback, Physiological
  • Computational Biology
  • Cell Cycle
  • Bioinformatics
  • 08 Information and Computing Sciences