Implementing an evidence-based risk assessment tool to predict chemotherapy-induced neutropenia in women with breast cancer.

Journal Article (Journal Article)

Background

Several studies have documented the efficacy of prophylactic granulocyte colony-stimulating factor in reducing rates of infections and risk of febrile neutropenia. An appropriate risk assessment model is pivotal to identify high-risk patients who would require granulocyte colony-stimulating factor prophylaxis.

Objective

The objectives of the study were to develop, implement, and evaluate a risk assessment model for neutropenic events in breast cancer patients who were receiving myelosuppressive chemotherapy.

Methods

During the study period, neutropenia risk was assessed for breast cancer patients by using an innovative risk model before the first cycle of chemotherapy. A stepwise logistic regression model was performed to determine significant factors for the prediction.

Results

A total of 119 patients were evaluated for neutropenia risk between August 2010 and December 2010. Twenty-nine percent (35/119) of the patients have experienced at least 1 neutropenic event during the initial 3 cycles of chemotherapy. Based on the logistic regression model, only the risk score was retained as the significant predictor; the probability of an individual patient developing neutropenic events increased 1.24 times by increasing 1 score number (odds ratio, 1.24; with 95% confidence interval, 1.063-1.457).

Conclusions

Based on the examination of different cutoff points, the performance of the risk model is best when the risk threshold is set at 6, which was found to have a sensitivity of 0.49 and a specificity of 0.69; the misclassification rate was 0.37, with a positive predictive value of 0.40 and a negative predictive value of 0.76.

Implications for practice

The results of this project support incorporating the discussed risk assessment model into routine nursing assessments to prevent neutropenic complications.

Full Text

Duke Authors

Cited Authors

  • Chang, L-L; Schneider, SM; Chiang, S-C; Horng, C-F

Published Date

  • May 2013

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 198 - 205

PubMed ID

  • 23051869

Pubmed Central ID

  • 23051869

Electronic International Standard Serial Number (EISSN)

  • 1538-9804

International Standard Serial Number (ISSN)

  • 0162-220X

Digital Object Identifier (DOI)

  • 10.1097/ncc.0b013e3182642d98

Language

  • eng