Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory network states.


Journal Article (Review)

Gastrulation in the sea urchin begins with ingression of the primary mesenchyme cells (PMCs) at the vegetal pole of the embryo. After entering the blastocoel the PMCs migrate, form a syncitium, and synthesize the skeleton of the embryo. Several hours after the PMCs ingress the vegetal plate buckles to initiate invagination of the archenteron. That morphogenetic process occurs in several steps. The nonskeletogenic cells produce the initial inbending of the vegetal plate. Endoderm cells then rearrange and extend the length of the gut across the blastocoel to a target near the animal pole. Finally, cells that will form part of the midgut and hindgut are added to complete gastrulation. Later, the stomodeum invaginates from the oral ectoderm and fuses with the foregut to complete the archenteron. In advance of, and during these morphogenetic events, an increasingly complex input of transcription factors controls the specification and the cell biological events that conduct the gastrulation movements.

Full Text

Duke Authors

Cited Authors

  • Lyons, DC; Kaltenbach, SL; McClay, DR

Published Date

  • March 2012

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 231 - 252

PubMed ID

  • 23801438

Pubmed Central ID

  • 23801438

Electronic International Standard Serial Number (EISSN)

  • 1759-7692

International Standard Serial Number (ISSN)

  • 1759-7684

Digital Object Identifier (DOI)

  • 10.1002/wdev.18


  • eng