The evolution of genes in branched metabolic pathways.

Published

Journal Article

Simulation models of the evolution of genes in a branched metabolic pathway subject to stabilizing selection on flux are described and analyzed. The models are based either on metabolic control theory (MCT), with the assumption that enzymes are far from saturation, or on Michaelis-Menten kinetics, which allows for saturation and near saturation. Several predictions emerge from the models: (1) flux control evolves to be concentrated at pathway branch points, including the first enzyme in the pathway. (2) When flux is far from its optimum, adaptive substitutions occur disproportionately often in branching enzymes. (3) When flux is near its optimum, adaptive substitutions occur disproportionately often in nonbranching enzymes. (4) Slightly deleterious substitutions occur disproportionately often in nonbranching enzymes. (5) In terms of both flux control and patterns of substitution, pathway branches are similar to those predicted for linear pathways. These predictions provide null hypotheses for empirical examination of the evolution of genes in metabolic pathways.

Full Text

Duke Authors

Cited Authors

  • Rausher, MD

Published Date

  • January 2013

Published In

Volume / Issue

  • 67 / 1

Start / End Page

  • 34 - 48

PubMed ID

  • 23289560

Pubmed Central ID

  • 23289560

Electronic International Standard Serial Number (EISSN)

  • 1558-5646

International Standard Serial Number (ISSN)

  • 0014-3820

Digital Object Identifier (DOI)

  • 10.1111/j.1558-5646.2012.01771.x

Language

  • eng