How genes influence life span: the biodemography of human survival.
Journal Article
Background
In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear.Data and method
A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort.Results
Age-specific survival curves considered as functions of the number of longevity alleles exhibit regularities known in demography as "rectangularization" of survival curves. The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance.Conclusion
Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits.Full Text
Duke Authors
- Arbeev, Konstantin
- Land, Kenneth C.
- Stallard, Patrick J. Eric
- Ukraintseva, Svetlana
- Wu, Dequing
- Yashin, Anatoli I.
Cited Authors
- Yashin, AI; Wu, D; Arbeev, KG; Stallard, E; Land, KC; Ukraintseva, SV
Published Date
- August 2012
Published In
Volume / Issue
- 15 / 4
Start / End Page
- 374 - 380
PubMed ID
- 22607627
Pubmed Central ID
- 22607627
Electronic International Standard Serial Number (EISSN)
- 1557-8577
International Standard Serial Number (ISSN)
- 1549-1684
Digital Object Identifier (DOI)
- 10.1089/rej.2011.1290
Language
- eng