Cowpox virus induces interleukin-10 both in vitro and in vivo.
Published
Journal Article
Cowpox virus infection induces interleukin-10 (IL-10) production from mouse bone marrow-derived dendritic cells (BMDCs) or cells of the mouse macrophage line (RAW264.7) at about 1800 pg/ml, whereas infections with vaccinia virus (strains WR or MVA) induced much less IL-10. Similarly, in vivo, IL-10 levels in bronchoalveolar lavage fluids of mice infected with cowpox virus were significantly higher than those after vaccinia virus infection. However, after intranasal cowpox virus infection, although dendritic and T-cell accumulations in the lungs of IL-10 deficient mice were greater than those in wild-type mice, weight-loss and viral burdens were not significantly different. IL-10 deficient mice were more susceptible than wild-type mice to re-infection with cowpox virus even though titers of neutralizing antibodies and virus-specific CD8 T cells were similar between IL-10 deficient and wild-type mice. Greater bronchopneumonia in IL-10 deficient mice than wild-type mice suggests that IL-10 contributes to the suppression of immunopathology in the lungs.
Full Text
Duke Authors
Cited Authors
- Spesock, AH; Barefoot, BE; Ray, CA; Kenan, DJ; Gunn, MD; Ramsburg, EA; Pickup, DJ
Published Date
- August 15, 2011
Published In
Volume / Issue
- 417 / 1
Start / End Page
- 87 - 97
PubMed ID
- 21658738
Pubmed Central ID
- 21658738
Electronic International Standard Serial Number (EISSN)
- 1096-0341
Digital Object Identifier (DOI)
- 10.1016/j.virol.2011.05.010
Language
- eng
Conference Location
- United States