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Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.

Publication ,  Journal Article
McLachlan, JB; Hart, JP; Pizzo, SV; Shelburne, CP; Staats, HF; Gunn, MD; Abraham, SN
Published in: Nat Immunol
December 2003

Palpable swelling of regional lymph nodes is a common sequela of microbial infections but the mechanism responsible for the sequestration and subsequent coordination of lymphocyte responses within these dynamic structures remains poorly understood. Here we show that draining lymph nodes of mast cell-deficient mice did not demonstrate swelling after intradermal bacterial challenge. Testing of individual mast cell-derived products in this model indicated that tumor necrosis factor was the main mediator of nodal hypertrophy, whereas tryptase and histamine had no effect. After peripheral mast cell activation, both tumor necrosis factor concentrations and the recruitment of circulating T cells were increased within draining nodes. These results show a critical function for peripheral mast cell-derived tumor necrosis factor in regulating the hypertrophy of draining lymph nodes during infection.

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Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

December 2003

Volume

4

Issue

12

Start / End Page

1199 / 1205

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Reverse Transcriptase Polymerase Chain Reaction
  • Mice
  • Mast Cells
  • Male
  • Lymph Nodes
  • Immunology
  • Immunoblotting
  • Hypertrophy
  • Flow Cytometry
 

Citation

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McLachlan, J. B., Hart, J. P., Pizzo, S. V., Shelburne, C. P., Staats, H. F., Gunn, M. D., & Abraham, S. N. (2003). Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol, 4(12), 1199–1205. https://doi.org/10.1038/ni1005
McLachlan, James B., Justin P. Hart, Salvatore V. Pizzo, Christopher P. Shelburne, Herman F. Staats, Michael D. Gunn, and Soman N. Abraham. “Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.Nat Immunol 4, no. 12 (December 2003): 1199–1205. https://doi.org/10.1038/ni1005.
McLachlan JB, Hart JP, Pizzo SV, Shelburne CP, Staats HF, Gunn MD, et al. Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol. 2003 Dec;4(12):1199–205.
McLachlan, James B., et al. “Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.Nat Immunol, vol. 4, no. 12, Dec. 2003, pp. 1199–205. Pubmed, doi:10.1038/ni1005.
McLachlan JB, Hart JP, Pizzo SV, Shelburne CP, Staats HF, Gunn MD, Abraham SN. Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol. 2003 Dec;4(12):1199–1205.

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

December 2003

Volume

4

Issue

12

Start / End Page

1199 / 1205

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Reverse Transcriptase Polymerase Chain Reaction
  • Mice
  • Mast Cells
  • Male
  • Lymph Nodes
  • Immunology
  • Immunoblotting
  • Hypertrophy
  • Flow Cytometry