HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design.
Published
Journal Article (Review)
Attempts to formulate a protective HIV-1 vaccine through classic vaccine design strategies have not been successful. Elicitation of HIV-1-specific broadly neutralizing antibodies (bnAbs) at high titers that are present before exposure might be required to achieve protection. Recently, the application of new technologies has facilitated the study of clonal lineages of HIV-1 envelope (Env) antibodies, which have provided insights into HIV-1 antibody development during infection and upon vaccination. Strategies are being developed for the analysis of infection and vaccine candidate-induced antibodies, their gene usage, and their maturation pathways such that this information can be used to attempt to guide rational vaccine design.
Full Text
Duke Authors
- Alam, S. Munir
- Bonsignori, Mattia
- Haynes, Barton Ford
- Liao, Hua-Xin
- Moody, Michael Anthony
- Tomaras, Georgia Doris
- Verkoczy, Laurent Karl
Cited Authors
- Bonsignori, M; Alam, SM; Liao, H-X; Verkoczy, L; Tomaras, GD; Haynes, BF; Moody, MA
Published Date
- November 2012
Published In
Volume / Issue
- 20 / 11
Start / End Page
- 532 - 539
PubMed ID
- 22981828
Pubmed Central ID
- 22981828
Electronic International Standard Serial Number (EISSN)
- 1878-4380
Digital Object Identifier (DOI)
- 10.1016/j.tim.2012.08.011
Language
- eng
Conference Location
- England