HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design.

Journal Article (Review)

Attempts to formulate a protective HIV-1 vaccine through classic vaccine design strategies have not been successful. Elicitation of HIV-1-specific broadly neutralizing antibodies (bnAbs) at high titers that are present before exposure might be required to achieve protection. Recently, the application of new technologies has facilitated the study of clonal lineages of HIV-1 envelope (Env) antibodies, which have provided insights into HIV-1 antibody development during infection and upon vaccination. Strategies are being developed for the analysis of infection and vaccine candidate-induced antibodies, their gene usage, and their maturation pathways such that this information can be used to attempt to guide rational vaccine design.

Full Text

Duke Authors

Cited Authors

  • Bonsignori, M; Alam, SM; Liao, H-X; Verkoczy, L; Tomaras, GD; Haynes, BF; Moody, MA

Published Date

  • November 2012

Published In

Volume / Issue

  • 20 / 11

Start / End Page

  • 532 - 539

PubMed ID

  • 22981828

Pubmed Central ID

  • 22981828

Electronic International Standard Serial Number (EISSN)

  • 1878-4380

International Standard Serial Number (ISSN)

  • 0966-842X

Digital Object Identifier (DOI)

  • 10.1016/j.tim.2012.08.011


  • eng