Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA.
Journal Article (Journal Article)
Killifish (Fundulus heteroclitus) from a highly contaminated site on the Elizabeth River are resistant to the acute toxicity and the cytochrome P4501A (CYP1A)-inducing activity of both the sediments from the site and chemically pure polycyclic aromatic hydrocarbons (PAHs). These effects are highly heritable for one generation, but heritable to a lesser degree by subsequent generations, in clean conditions in the laboratory. We show that offspring of this population of Elizabeth River killifish are also resistant to the teratogenicity and P4501A-inducing activity of PCB congener 126, a prototypical coplanar halogenated aromatic hydrocarbon (HAH). Furthermore, the pattern of greater resistance to acute toxicity and P4501A-inducing activity in the first generation and less in subsequent generations is also observed upon exposure to PCB-126.
Full Text
Duke Authors
Cited Authors
- Meyer, J; Di Giulio, R
Published Date
- September 2002
Published In
Volume / Issue
- 54 / 3-5
Start / End Page
- 621 - 626
PubMed ID
- 12408627
Electronic International Standard Serial Number (EISSN)
- 1879-0291
International Standard Serial Number (ISSN)
- 0141-1136
Digital Object Identifier (DOI)
- 10.1016/s0141-1136(02)00170-8
Language
- eng