Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics.


Journal Article

A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms.

Full Text

Duke Authors

Cited Authors

  • Burnett, KG; Bain, LJ; Baldwin, WS; Callard, GV; Cohen, S; Di Giulio, RT; Evans, DH; Gómez-Chiarri, M; Hahn, ME; Hoover, CA; Karchner, SI; Katoh, F; Maclatchy, DL; Marshall, WS; Meyer, JN; Nacci, DE; Oleksiak, MF; Rees, BB; Singer, TD; Stegeman, JJ; Towle, DW; Van Veld, PA; Vogelbein, WK; Whitehead, A; Winn, RN; Crawford, DL

Published Date

  • December 2007

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 257 - 286

PubMed ID

  • 18071578

Pubmed Central ID

  • 18071578

Electronic International Standard Serial Number (EISSN)

  • 1878-0407

International Standard Serial Number (ISSN)

  • 1878-0407

Digital Object Identifier (DOI)

  • 10.1016/j.cbd.2007.09.001


  • eng