Genetics in population health science: strategies and opportunities

Journal Article (Academic article)

Translational research is needed to leverage discoveries from the frontiers of genome science to improve public health. So far, public health researchers have largely ignored genetic discoveries, and geneticists have ignored important aspects of population health science. This mutual neglect should end. In this article, we discuss 3 areas where public health researchers can help to advance translation: (1) risk assessment: investigate genetic profiles as components in composite risk assessments; (2) targeted intervention: conduct life-course longitudinal studies to understand when genetic risks manifest in development and whether intervention during sensitive periods can have lasting effects; and (3) improved understanding of environmental causation: collaborate with geneticists on gene-environment interaction research. We illustrate with examples from our own research on obesity and smoking.

Full Text

Duke Authors

Cited Authors

  • Belsky, DW; Moffitt, TE; Caspi, A

Published Date

  • October 2013

Published In

Volume / Issue

  • 103 Suppl 1 /

Start / End Page

  • S73 - 83

PubMed ID

  • 23927511

Pubmed Central ID

  • PMC3786748

International Standard Serial Number (ISSN)

  • 1541-0048

Digital Object Identifier (DOI)

  • 10.2105/AJPH.2012.301139


  • eng