Neural correlates of genetically abnormal social cognition in Williams syndrome.
Publication
, Journal Article
Meyer-Lindenberg, A; Hariri, AR; Munoz, KE; Mervis, CB; Mattay, VS; Morris, CA; Berman, KF
Published in: Nature neuroscience
August 2005
Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior.
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Published In
Nature neuroscience
DOI
EISSN
1546-1726
ISSN
1097-6256
Publication Date
August 2005
Volume
8
Issue
8
Start / End Page
991 / 993
Related Subject Headings
- Williams Syndrome
- Social Behavior
- Prefrontal Cortex
- Neurology & Neurosurgery
- Magnetic Resonance Imaging
- Humans
- Frontal Lobe
- Cognition
- Case-Control Studies
- Brain Mapping
Citation
APA
Chicago
ICMJE
MLA
NLM
Meyer-Lindenberg, A., Hariri, A. R., Munoz, K. E., Mervis, C. B., Mattay, V. S., Morris, C. A., & Berman, K. F. (2005). Neural correlates of genetically abnormal social cognition in Williams syndrome. Nature Neuroscience, 8(8), 991–993. https://doi.org/10.1038/nn1494
Meyer-Lindenberg, Andreas, Ahmad R. Hariri, Karen E. Munoz, Carolyn B. Mervis, Venkata S. Mattay, Colleen A. Morris, and Karen Faith Berman. “Neural correlates of genetically abnormal social cognition in Williams syndrome.” Nature Neuroscience 8, no. 8 (August 2005): 991–93. https://doi.org/10.1038/nn1494.
Meyer-Lindenberg A, Hariri AR, Munoz KE, Mervis CB, Mattay VS, Morris CA, et al. Neural correlates of genetically abnormal social cognition in Williams syndrome. Nature neuroscience. 2005 Aug;8(8):991–3.
Meyer-Lindenberg, Andreas, et al. “Neural correlates of genetically abnormal social cognition in Williams syndrome.” Nature Neuroscience, vol. 8, no. 8, Aug. 2005, pp. 991–93. Epmc, doi:10.1038/nn1494.
Meyer-Lindenberg A, Hariri AR, Munoz KE, Mervis CB, Mattay VS, Morris CA, Berman KF. Neural correlates of genetically abnormal social cognition in Williams syndrome. Nature neuroscience. 2005 Aug;8(8):991–993.
Published In
Nature neuroscience
DOI
EISSN
1546-1726
ISSN
1097-6256
Publication Date
August 2005
Volume
8
Issue
8
Start / End Page
991 / 993
Related Subject Headings
- Williams Syndrome
- Social Behavior
- Prefrontal Cortex
- Neurology & Neurosurgery
- Magnetic Resonance Imaging
- Humans
- Frontal Lobe
- Cognition
- Case-Control Studies
- Brain Mapping