Neural correlates of genetically abnormal social cognition in Williams syndrome.
Journal Article (Journal Article)
Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior.
Full Text
Duke Authors
Cited Authors
- Meyer-Lindenberg, A; Hariri, AR; Munoz, KE; Mervis, CB; Mattay, VS; Morris, CA; Berman, KF
Published Date
- August 2005
Published In
Volume / Issue
- 8 / 8
Start / End Page
- 991 - 993
PubMed ID
- 16007084
Electronic International Standard Serial Number (EISSN)
- 1546-1726
International Standard Serial Number (ISSN)
- 1097-6256
Digital Object Identifier (DOI)
- 10.1038/nn1494
Language
- eng