Understanding risk for psychopathology through imaging gene-environment interactions.

Journal Article (Review;Journal Article)

Examining the interplay of genes, experience and the brain is crucial to understanding psychopathology. We review the recent gene-environment interaction (G×E) and imaging genetics literature with the goal of developing models to bridge these approaches within single imaging gene-environment interaction (IG×E) studies. We explore challenges inherent in both G×E and imaging genetics and highlight studies that address these limitations. In specifying IG×E models, we examine statistical methods for combining these approaches, and explore plausible biological mechanisms (e.g. epigenetics) through which these conditional mechanisms can be understood. Finally, we discuss the potential contribution that IG×E studies can make to understanding psychopathology and developing more personalized and effective prevention and treatment.

Full Text

Duke Authors

Cited Authors

  • Hyde, LW; Bogdan, R; Hariri, AR

Published Date

  • September 2011

Published In

Volume / Issue

  • 15 / 9

Start / End Page

  • 417 - 427

PubMed ID

  • 21839667

Pubmed Central ID

  • PMC3163727

Electronic International Standard Serial Number (EISSN)

  • 1879-307X

International Standard Serial Number (ISSN)

  • 1364-6613

Digital Object Identifier (DOI)

  • 10.1016/j.tics.2011.07.001


  • eng