Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.


Journal Article

We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.

Full Text

Duke Authors

Cited Authors

  • Fisher, PM; Meltzer, CC; Ziolko, SK; Price, JC; Moses-Kolko, EL; Berga, SL; Hariri, AR

Published Date

  • November 2006

Published In

Volume / Issue

  • 9 / 11

Start / End Page

  • 1362 - 1363

PubMed ID

  • 17013380

Pubmed Central ID

  • 17013380

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn1780


  • eng