Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.
Publication
, Journal Article
Fisher, PM; Meltzer, CC; Ziolko, SK; Price, JC; Moses-Kolko, EL; Berga, SL; Hariri, AR
Published in: Nature neuroscience
November 2006
We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
Duke Scholars
Published In
Nature neuroscience
DOI
EISSN
1546-1726
ISSN
1097-6256
Publication Date
November 2006
Volume
9
Issue
11
Start / End Page
1362 / 1363
Related Subject Headings
- Serotonin Antagonists
- Receptor, Serotonin, 5-HT1A
- Pyridines
- Positron-Emission Tomography
- Piperazines
- Oxygen
- Neurology & Neurosurgery
- Magnetic Resonance Imaging
- Humans
- Homeostasis
Citation
APA
Chicago
ICMJE
MLA
NLM
Fisher, P. M., Meltzer, C. C., Ziolko, S. K., Price, J. C., Moses-Kolko, E. L., Berga, S. L., & Hariri, A. R. (2006). Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity. Nature Neuroscience, 9(11), 1362–1363. https://doi.org/10.1038/nn1780
Fisher, P. M., C. C. Meltzer, S. K. Ziolko, J. C. Price, E. L. Moses-Kolko, S. L. Berga, and A. R. Hariri. “Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.” Nature Neuroscience 9, no. 11 (November 2006): 1362–63. https://doi.org/10.1038/nn1780.
Fisher PM, Meltzer CC, Ziolko SK, Price JC, Moses-Kolko EL, Berga SL, et al. Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity. Nature neuroscience. 2006 Nov;9(11):1362–3.
Fisher, P. M., et al. “Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.” Nature Neuroscience, vol. 9, no. 11, Nov. 2006, pp. 1362–63. Epmc, doi:10.1038/nn1780.
Fisher PM, Meltzer CC, Ziolko SK, Price JC, Moses-Kolko EL, Berga SL, Hariri AR. Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity. Nature neuroscience. 2006 Nov;9(11):1362–1363.
Published In
Nature neuroscience
DOI
EISSN
1546-1726
ISSN
1097-6256
Publication Date
November 2006
Volume
9
Issue
11
Start / End Page
1362 / 1363
Related Subject Headings
- Serotonin Antagonists
- Receptor, Serotonin, 5-HT1A
- Pyridines
- Positron-Emission Tomography
- Piperazines
- Oxygen
- Neurology & Neurosurgery
- Magnetic Resonance Imaging
- Humans
- Homeostasis