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Parental education predicts corticostriatal functionality in adulthood.

Publication ,  Journal Article
Gianaros, PJ; Manuck, SB; Sheu, LK; Kuan, DCH; Votruba-Drzal, E; Craig, AE; Hariri, AR
Published in: Cerebral cortex (New York, N.Y. : 1991)
April 2011

Socioeconomic disadvantage experienced in early development predicts ill health in adulthood. However, the neurobiological pathways linking early disadvantage to adult health remain unclear. Lower parental education-a presumptive indicator of early socioeconomic disadvantage-predicts health-impairing adult behaviors, including tobacco and alcohol dependencies. These behaviors depend, in part, on the functionality of corticostriatal brain systems that 1) show developmental plasticity and early vulnerability, 2) process reward-related information, and 3) regulate impulsive decisions and actions. Hence, corticostriatal functionality in adulthood may covary directly with indicators of early socioeconomic disadvantage, particularly lower parental education. Here, we tested the covariation between parental education and corticostriatal activation and connectivity in 76 adults without confounding clinical syndromes. Corticostriatal activation and connectivity were assessed during the processing of stimuli signaling monetary gains (positive feedback [PF]) and losses (negative feedback). After accounting for participants' own education and other explanatory factors, lower parental education predicted reduced activation in anterior cingulate and dorsomedial prefrontal cortices during PF, along with reduced connectivity between these cortices and orbitofrontal and striatal areas implicated in reward processing and impulse regulation. In speculation, adult alterations in corticostriatal functionality may represent facets of a neurobiological endophenotype linked to socioeconomic conditions of early development.

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Published In

Cerebral cortex (New York, N.Y. : 1991)

DOI

EISSN

1460-2199

ISSN

1047-3211

Publication Date

April 2011

Volume

21

Issue

4

Start / End Page

896 / 910

Related Subject Headings

  • Socioeconomic Factors
  • Parents
  • Neural Pathways
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Experimental Psychology
  • Educational Status
 

Citation

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Gianaros, P. J., Manuck, S. B., Sheu, L. K., Kuan, D. C. H., Votruba-Drzal, E., Craig, A. E., & Hariri, A. R. (2011). Parental education predicts corticostriatal functionality in adulthood. Cerebral Cortex (New York, N.Y. : 1991), 21(4), 896–910. https://doi.org/10.1093/cercor/bhq160
Gianaros, Peter J., Stephen B. Manuck, Lei K. Sheu, Dora C. H. Kuan, Elizabeth Votruba-Drzal, Anna E. Craig, and Ahmad R. Hariri. “Parental education predicts corticostriatal functionality in adulthood.Cerebral Cortex (New York, N.Y. : 1991) 21, no. 4 (April 2011): 896–910. https://doi.org/10.1093/cercor/bhq160.
Gianaros PJ, Manuck SB, Sheu LK, Kuan DCH, Votruba-Drzal E, Craig AE, et al. Parental education predicts corticostriatal functionality in adulthood. Cerebral cortex (New York, NY : 1991). 2011 Apr;21(4):896–910.
Gianaros, Peter J., et al. “Parental education predicts corticostriatal functionality in adulthood.Cerebral Cortex (New York, N.Y. : 1991), vol. 21, no. 4, Apr. 2011, pp. 896–910. Epmc, doi:10.1093/cercor/bhq160.
Gianaros PJ, Manuck SB, Sheu LK, Kuan DCH, Votruba-Drzal E, Craig AE, Hariri AR. Parental education predicts corticostriatal functionality in adulthood. Cerebral cortex (New York, NY : 1991). 2011 Apr;21(4):896–910.
Journal cover image

Published In

Cerebral cortex (New York, N.Y. : 1991)

DOI

EISSN

1460-2199

ISSN

1047-3211

Publication Date

April 2011

Volume

21

Issue

4

Start / End Page

896 / 910

Related Subject Headings

  • Socioeconomic Factors
  • Parents
  • Neural Pathways
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Experimental Psychology
  • Educational Status