Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults.

Published

Journal Article

BACKGROUND: In animals, dendritic arborization and levels of brain derived neurotrophic factor are positively associated with intake of the omega-3 fatty acids. Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity. METHODS: Fifty-five healthy adults completed two 24h dietary recall interviews. Intake of long-chain omega-3 fatty acids was categorized by tertiles. Regional gray matter volumes in a putative emotional brain circuitry comprised of the anterior cingulate cortex (ACC), amygdala and hippocampus were calculated using optimized voxel-based morphometry on high-resolution structural magnetic resonance images. RESULTS: Region of interest analyses revealed positive associations between reported dietary omega-3 intake and gray matter volume in the subgenual ACC, the right hippocampus and the right amygdala, adjusted for total gray matter volume of brain. Unconstrained whole-brain analyses confirmed that higher intake of omega-3 fatty acids was selectively associated with increased greater gray matter volume in these and not other regions. CONCLUSIONS: Higher reported consumption of the long-chain omega-3 fatty acids is associated with greater gray matter volume in nodes of a corticolimbic circuitry supporting emotional arousal and regulation. Such associations may mediate previously observed effects of omega-3 fatty acids on memory, mood and affect regulation.

Full Text

Duke Authors

Cited Authors

  • Conklin, SM; Gianaros, PJ; Brown, SM; Yao, JK; Hariri, AR; Manuck, SB; Muldoon, MF

Published Date

  • June 2, 2007

Published In

Volume / Issue

  • 421 / 3

Start / End Page

  • 209 - 212

PubMed ID

  • 17574755

Pubmed Central ID

  • 17574755

Electronic International Standard Serial Number (EISSN)

  • 1872-7972

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2007.04.086

Language

  • eng