Genetics of emotional regulation: the role of the serotonin transporter in neural function.
Identifying biological mechanisms through which genes lead to individual differences in emotional behavior is paramount to our understanding of how such differences confer risk for neuropsychiatric illness. The emergence of techniques such as in vivo imaging of brain function in humans and genetic engineering in rodents has provided important new insights into the impact of serotonin (5-HT), a key modulator of emotional behavior, on neural systems subserving anxiety and depression. A major finding has been the discovery of genetic variation in a crucial regulatory molecule within the 5-HT system, the 5HT transporter (5-HTT), and its influence on emotional traits. The study of the 5-HTT provides a new foundation for understanding the neurobiological and genetic basis of emotional regulation and affective illness.
Duke Scholars
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Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Mood Disorders
- Models, Neurological
- Humans
- Genetic Variation
- Experimental Psychology
- Emotions
- Animals
- Amygdala
- 5204 Cognitive and computational psychology
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Mood Disorders
- Models, Neurological
- Humans
- Genetic Variation
- Experimental Psychology
- Emotions
- Animals
- Amygdala
- 5204 Cognitive and computational psychology