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Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala.

Publication ,  Journal Article
Gianaros, PJ; Hariri, AR; Sheu, LK; Muldoon, MF; Sutton-Tyrrell, K; Manuck, SB
Published in: Biological psychiatry
June 2009

Cardiovascular disease (CVD) is a major source of medical comorbidity for patients with mood and anxiety disorders, and it remains the leading public health burden for the general population in industrialized nations. Indirect neurobiological evidence suggests that preclinical risk for atherosclerosis, the main contributor to CVD, may be conferred by interindividual variation in the functionality of the amygdala, a brain system jointly involved in processing behaviorally salient stimuli and regulating the cardiovascular system.In a neuroimaging study of 36 middle-aged adults (18 women) who were screened for confounding clinical cardiovascular and psychiatric disorders, we examined the direct covariation between a marker of preclinical atherosclerosis, carotid artery intima-media thickness (IMT), and interindividual variation in amygdala reactivity and functional connectivity assessed during the processing of behaviorally salient stimuli (angry and fearful facial expressions).After accounting for traditional CVD risk factors, a thickening of carotid IMT across individuals covaried with greater amygdala reactivity and a more positive functional connectivity between the amygdala and perigenual anterior cingulate cortex, a corticolimbic area also implicated in behavioral salience processing and cardiovascular regulation.Individual differences in amygdala reactivity and functional connectivity may reflect facets of a novel, systems-level neural phenotype conferring risk for atherosclerosis and CVD.

Duke Scholars

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

June 2009

Volume

65

Issue

11

Start / End Page

943 / 950

Related Subject Headings

  • Ultrasonography
  • Tunica Media
  • Statistics as Topic
  • Risk Factors
  • Psychiatry
  • Oxygen
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Individuality
 

Citation

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ICMJE
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Gianaros, P. J., Hariri, A. R., Sheu, L. K., Muldoon, M. F., Sutton-Tyrrell, K., & Manuck, S. B. (2009). Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala. Biological Psychiatry, 65(11), 943–950. https://doi.org/10.1016/j.biopsych.2008.10.007
Gianaros, Peter J., Ahmad R. Hariri, Lei K. Sheu, Matthew F. Muldoon, Kim Sutton-Tyrrell, and Stephen B. Manuck. “Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala.Biological Psychiatry 65, no. 11 (June 2009): 943–50. https://doi.org/10.1016/j.biopsych.2008.10.007.
Gianaros PJ, Hariri AR, Sheu LK, Muldoon MF, Sutton-Tyrrell K, Manuck SB. Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala. Biological psychiatry. 2009 Jun;65(11):943–50.
Gianaros, Peter J., et al. “Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala.Biological Psychiatry, vol. 65, no. 11, June 2009, pp. 943–50. Epmc, doi:10.1016/j.biopsych.2008.10.007.
Gianaros PJ, Hariri AR, Sheu LK, Muldoon MF, Sutton-Tyrrell K, Manuck SB. Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala. Biological psychiatry. 2009 Jun;65(11):943–950.
Journal cover image

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

June 2009

Volume

65

Issue

11

Start / End Page

943 / 950

Related Subject Headings

  • Ultrasonography
  • Tunica Media
  • Statistics as Topic
  • Risk Factors
  • Psychiatry
  • Oxygen
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Individuality