Dopamine in amygdala gates limbic processing of aversive stimuli in humans.

Journal Article (Journal Article)

Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[(18)F]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level-dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.

Full Text

Duke Authors

Cited Authors

  • Kienast, T; Hariri, AR; Schlagenhauf, F; Wrase, J; Sterzer, P; Buchholz, HG; Smolka, MN; Gründer, G; Cumming, P; Kumakura, Y; Bartenstein, P; Dolan, RJ; Heinz, A

Published Date

  • December 2008

Published In

Volume / Issue

  • 11 / 12

Start / End Page

  • 1381 - 1382

PubMed ID

  • 18978778

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn.2222


  • eng