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Dopamine in amygdala gates limbic processing of aversive stimuli in humans.

Publication ,  Journal Article
Kienast, T; Hariri, AR; Schlagenhauf, F; Wrase, J; Sterzer, P; Buchholz, HG; Smolka, MN; Gründer, G; Cumming, P; Kumakura, Y; Bartenstein, P ...
Published in: Nature neuroscience
December 2008

Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[(18)F]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level-dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.

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Published In

Nature neuroscience

DOI

EISSN

1546-1726

ISSN

1097-6256

Publication Date

December 2008

Volume

11

Issue

12

Start / End Page

1381 / 1382

Related Subject Headings

  • Psychophysics
  • Positron-Emission Tomography
  • Oxygen
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Limbic System
  • Image Processing, Computer-Assisted
  • Humans
 

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Kienast, T., Hariri, A. R., Schlagenhauf, F., Wrase, J., Sterzer, P., Buchholz, H. G., … Heinz, A. (2008). Dopamine in amygdala gates limbic processing of aversive stimuli in humans. Nature Neuroscience, 11(12), 1381–1382. https://doi.org/10.1038/nn.2222
Kienast, Thorsten, Ahmad R. Hariri, Florian Schlagenhauf, Jana Wrase, Philipp Sterzer, Hans Georg Buchholz, Michael N. Smolka, et al. “Dopamine in amygdala gates limbic processing of aversive stimuli in humans.Nature Neuroscience 11, no. 12 (December 2008): 1381–82. https://doi.org/10.1038/nn.2222.
Kienast T, Hariri AR, Schlagenhauf F, Wrase J, Sterzer P, Buchholz HG, et al. Dopamine in amygdala gates limbic processing of aversive stimuli in humans. Nature neuroscience. 2008 Dec;11(12):1381–2.
Kienast, Thorsten, et al. “Dopamine in amygdala gates limbic processing of aversive stimuli in humans.Nature Neuroscience, vol. 11, no. 12, Dec. 2008, pp. 1381–82. Epmc, doi:10.1038/nn.2222.
Kienast T, Hariri AR, Schlagenhauf F, Wrase J, Sterzer P, Buchholz HG, Smolka MN, Gründer G, Cumming P, Kumakura Y, Bartenstein P, Dolan RJ, Heinz A. Dopamine in amygdala gates limbic processing of aversive stimuli in humans. Nature neuroscience. 2008 Dec;11(12):1381–1382.

Published In

Nature neuroscience

DOI

EISSN

1546-1726

ISSN

1097-6256

Publication Date

December 2008

Volume

11

Issue

12

Start / End Page

1381 / 1382

Related Subject Headings

  • Psychophysics
  • Positron-Emission Tomography
  • Oxygen
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Limbic System
  • Image Processing, Computer-Assisted
  • Humans