A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity.


Journal Article

Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Genetic variation in the human TPH2 gene (hTPH2) has been associated with altered in vitro enzyme activity as well as increased risk for mood disorders. Here, we provide the first in vivo evidence that a relatively frequent regulatory variant (G(-844)T) of hTPH2 biases the reactivity of the amygdala, a neural structure critical in the generation and regulation of emotional behaviors.

Full Text

Duke Authors

Cited Authors

  • Brown, SM; Peet, E; Manuck, SB; Williamson, DE; Dahl, RE; Ferrell, RE; Hariri, AR

Published Date

  • September 2005

Published In

Volume / Issue

  • 10 / 9

Start / End Page

  • 884 - 805

PubMed ID

  • 16044172

Pubmed Central ID

  • 16044172

Electronic International Standard Serial Number (EISSN)

  • 1476-5578

International Standard Serial Number (ISSN)

  • 1359-4184

Digital Object Identifier (DOI)

  • 10.1038/sj.mp.4001716


  • eng