A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity.
Publication
, Journal Article
Brown, SM; Peet, E; Manuck, SB; Williamson, DE; Dahl, RE; Ferrell, RE; Hariri, AR
Published in: Molecular psychiatry
September 2005
Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Genetic variation in the human TPH2 gene (hTPH2) has been associated with altered in vitro enzyme activity as well as increased risk for mood disorders. Here, we provide the first in vivo evidence that a relatively frequent regulatory variant (G(-844)T) of hTPH2 biases the reactivity of the amygdala, a neural structure critical in the generation and regulation of emotional behaviors.
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Published In
Molecular psychiatry
DOI
EISSN
1476-5578
ISSN
1359-4184
Publication Date
September 2005
Volume
10
Issue
9
Start / End Page
884 / 805
Related Subject Headings
- Tryptophan Hydroxylase
- Sequence Deletion
- Psychiatry
- Oxygen
- Magnetic Resonance Imaging
- Humans
- Genotype
- Genetic Variation
- Gene Frequency
- Emotions
Citation
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NLM
Brown, S. M., Peet, E., Manuck, S. B., Williamson, D. E., Dahl, R. E., Ferrell, R. E., & Hariri, A. R. (2005). A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular Psychiatry, 10(9), 884–805. https://doi.org/10.1038/sj.mp.4001716
Brown, S. M., E. Peet, S. B. Manuck, D. E. Williamson, R. E. Dahl, R. E. Ferrell, and A. R. Hariri. “A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity.” Molecular Psychiatry 10, no. 9 (September 2005): 884–805. https://doi.org/10.1038/sj.mp.4001716.
Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, et al. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular psychiatry. 2005 Sep;10(9):884–805.
Brown, S. M., et al. “A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity.” Molecular Psychiatry, vol. 10, no. 9, Sept. 2005, pp. 884–805. Epmc, doi:10.1038/sj.mp.4001716.
Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular psychiatry. 2005 Sep;10(9):884–805.
Published In
Molecular psychiatry
DOI
EISSN
1476-5578
ISSN
1359-4184
Publication Date
September 2005
Volume
10
Issue
9
Start / End Page
884 / 805
Related Subject Headings
- Tryptophan Hydroxylase
- Sequence Deletion
- Psychiatry
- Oxygen
- Magnetic Resonance Imaging
- Humans
- Genotype
- Genetic Variation
- Gene Frequency
- Emotions