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Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity.

Publication ,  Journal Article
Nikolova, YS; Ferrell, RE; Manuck, SB; Hariri, AR
Published in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
August 2011

Research integrating neuroimaging and molecular genetics has yielded important insights into how variability in brain chemistry predicts individual differences in brain function, behavior and related risk for psychopathology. However, existing studies have been limited by their focus on the independent effects of single polymorphisms with modest impact on brain chemistry. Here, we explored the effects of five functional polymorphisms affecting dopamine (DA) signaling on reward-related ventral striatum (VS) reactivity, measured with BOLD fMRI, in a sample of 69 Caucasians. We also compiled individual multilocus genetic profile scores reflecting the additive effects of alleles conferring relatively increased DA signaling across the five polymorphic loci: DAT1 9-repeat, DRD4 7-repeat, DRD2 -141C Del, DRD2 Taq1A C (A2), and COMT (158)Met. These multilocus DA profile scores accounted for 10.9% of the inter-individual variability in reward-related VS reactivity. In contrast, none of the individual polymorphisms accounted for significant variability. Our results show that biologically informed multilocus genetic profiles have unique promise as indices of variability in brain chemistry that may yield advances in mapping individual differences in behaviorally relevant brain function. In turn, such genetic profiles may fuel gene-environment interactions research establishing trajectories of risk for psychopathology.

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Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

August 2011

Volume

36

Issue

9

Start / End Page

1940 / 1947

Related Subject Headings

  • Signal Transduction
  • Receptors, Dopamine D4
  • Receptors, Dopamine D2
  • Psychiatry
  • Predictive Value of Tests
  • Polymorphism, Genetic
  • Mood Disorders
  • Middle Aged
  • Male
  • Humans
 

Citation

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ICMJE
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Nikolova, Y. S., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2011). Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 36(9), 1940–1947. https://doi.org/10.1038/npp.2011.82
Nikolova, Yuliya S., Robert E. Ferrell, Stephen B. Manuck, and Ahmad R. Hariri. “Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 36, no. 9 (August 2011): 1940–47. https://doi.org/10.1038/npp.2011.82.
Nikolova YS, Ferrell RE, Manuck SB, Hariri AR. Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011 Aug;36(9):1940–7.
Nikolova, Yuliya S., et al. “Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 36, no. 9, Aug. 2011, pp. 1940–47. Epmc, doi:10.1038/npp.2011.82.
Nikolova YS, Ferrell RE, Manuck SB, Hariri AR. Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011 Aug;36(9):1940–1947.

Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

August 2011

Volume

36

Issue

9

Start / End Page

1940 / 1947

Related Subject Headings

  • Signal Transduction
  • Receptors, Dopamine D4
  • Receptors, Dopamine D2
  • Psychiatry
  • Predictive Value of Tests
  • Polymorphism, Genetic
  • Mood Disorders
  • Middle Aged
  • Male
  • Humans