Skip to main content
Journal cover image

Developmental imaging genetics: challenges and promises for translational research.

Publication ,  Journal Article
Viding, E; Williamson, DE; Hariri, AR
Published in: Development and psychopathology
January 2006

Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework. Herein, we begin by outlining an experimental strategy by which genetic effects on brain function can be explored using neuroimaging, namely, imaging genetics. We next describe some major findings in imaging genetics to highlight the effectiveness of this strategy for delineating biological pathways and mechanisms by which individual differences in brain function emerge and potentially bias behavior and risk for psychiatric illness. We then discuss the importance of applying imaging genetics to the study of psychopathology within a developmental framework. By beginning to move toward a systems-level approach to understanding pathways to behavioral outcomes as they are expressed across development, it is anticipated that we will move closer to understanding the complexities of the specific mechanisms involved in the etiology of psychiatric disease. Despite the numerous challenges that lie ahead, we believe that developmental imaging genetics has potential to yield highly informative results that will ultimately translate into public health benefits. We attempt to set out guidelines and provide exemplars that may help in designing fruitful translational research applications that incorporate a developmental imaging genetics strategy.

Duke Scholars

Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

January 2006

Volume

18

Issue

3

Start / End Page

877 / 892

Related Subject Headings

  • Serotonin
  • Research
  • Mental Disorders
  • Magnetic Resonance Imaging
  • Interdisciplinary Communication
  • Humans
  • Electroencephalography
  • Developmental & Child Psychology
  • Brain
  • Antisocial Personality Disorder
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Viding, E., Williamson, D. E., & Hariri, A. R. (2006). Developmental imaging genetics: challenges and promises for translational research. Development and Psychopathology, 18(3), 877–892. https://doi.org/10.1017/s0954579406060433
Viding, Essi, Douglas E. Williamson, and Ahmad R. Hariri. “Developmental imaging genetics: challenges and promises for translational research.Development and Psychopathology 18, no. 3 (January 2006): 877–92. https://doi.org/10.1017/s0954579406060433.
Viding E, Williamson DE, Hariri AR. Developmental imaging genetics: challenges and promises for translational research. Development and psychopathology. 2006 Jan;18(3):877–92.
Viding, Essi, et al. “Developmental imaging genetics: challenges and promises for translational research.Development and Psychopathology, vol. 18, no. 3, Jan. 2006, pp. 877–92. Epmc, doi:10.1017/s0954579406060433.
Viding E, Williamson DE, Hariri AR. Developmental imaging genetics: challenges and promises for translational research. Development and psychopathology. 2006 Jan;18(3):877–892.
Journal cover image

Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

January 2006

Volume

18

Issue

3

Start / End Page

877 / 892

Related Subject Headings

  • Serotonin
  • Research
  • Mental Disorders
  • Magnetic Resonance Imaging
  • Interdisciplinary Communication
  • Humans
  • Electroencephalography
  • Developmental & Child Psychology
  • Brain
  • Antisocial Personality Disorder