Organ cross talk in the critically ill: the heart and kidney.


Journal Article (Review)

Heart failure results in significant morbidity and mortality in the United States. Chronic heart failure is often complicated by renal insufficiency. Further, acute decompensated heart failure is often complicated by worsening renal function or the development of diuretic resistance. Heart failure complicated by renal dysfunction has a significantly worse prognosis. The pathophysiology underlying this so-called cardiorenal syndrome (CRS) is unclear. It likely involves a combination of maladaptive neurohormonal activation and renal homeostatic mechanisms. The treatment (including recombinant B-type natriuretic peptide, ultrafiltration, continuous furosemide infusions and vasopressin antagonists) has thus far been marginally successful at best. Further research into the mechanism and treatment of CRS is required.

Full Text

Duke Authors

Cited Authors

  • Kociol, R; Rogers, J; Shaw, A

Published Date

  • 2009

Published In

Volume / Issue

  • 27 / 4

Start / End Page

  • 311 - 320

PubMed ID

  • 19270450

Pubmed Central ID

  • 19270450

Electronic International Standard Serial Number (EISSN)

  • 1421-9735

Digital Object Identifier (DOI)

  • 10.1159/000207198


  • eng

Conference Location

  • Switzerland