Integrative systems biology: an attempt to describe a simple weed.

Journal Article (Review;Journal Article)

Genome-scale studies hold great promise for revealing novel plant biology. Because of the complexity of these techniques, numerous considerations need to be made before embarking on a study. Here we focus on the Arabidopsis model system because of the wealth of available genome-scale data. Many approaches are available that provide genome-scale information regarding the state of a given organism (e.g. genomics, epigenomics, transcriptomics, proteomics, metabolomics interactomics, ionomics, phenomics, etc.). Integration of all of these types of data will be necessary for a comprehensive description of Arabidopsis. In this review we propose that 'triangulation' among transcriptomics, proteomics and metabolomics is a meaningful approach for beginning this integrative analysis and uncovering a systems level perspective of Arabidopsis biology.

Full Text

Duke Authors

Cited Authors

  • Liberman, LM; Sozzani, R; Benfey, PN

Published Date

  • April 2012

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 162 - 167

PubMed ID

  • 22277598

Pubmed Central ID

  • PMC3435099

Electronic International Standard Serial Number (EISSN)

  • 1879-0356

International Standard Serial Number (ISSN)

  • 1369-5266

Digital Object Identifier (DOI)

  • 10.1016/j.pbi.2012.01.004


  • eng