A strategy to advance the evidence base in palliative medicine: formation of a palliative care research cooperative group.

Published

Journal Article

BACKGROUND: Palliative medicine has made rapid progress in establishing its scientific and clinical legitimacy, yet the evidence base to support clinical practice remains deficient in both the quantity and quality of published studies. Historically, the conduct of research in palliative care populations has been impeded by multiple barriers including health care system fragmentation, small number and size of potential sites for recruitment, vulnerability of the population, perceptions of inappropriateness, ethical concerns, and gate-keeping. METHODS: A group of experienced investigators with backgrounds in palliative care research convened to consider developing a research cooperative group as a mechanism for generating high-quality evidence on prioritized, clinically relevant topics in palliative care. RESULTS: The resulting Palliative Care Research Cooperative (PCRC) agreed on a set of core principles: active, interdisciplinary membership; commitment to shared research purposes; heterogeneity of participating sites; development of research capacity in participating sites; standardization of methodologies, such as consenting and data collection/management; agile response to research requests from government, industry, and investigators; focus on translation; education and training of future palliative care researchers; actionable results that can inform clinical practice and policy. Consensus was achieved on a first collaborative study, a randomized clinical trial of statin discontinuation versus continuation in patients with a prognosis of less than 6 months who are taking statins for primary or secondary prevention. This article describes the formation of the PCRC, highlighting processes and decisions taken to optimize the cooperative group's success.

Full Text

Duke Authors

Cited Authors

  • Abernethy, AP; Aziz, NM; Basch, E; Bull, J; Cleeland, CS; Currow, DC; Fairclough, D; Hanson, L; Hauser, J; Ko, D; Lloyd, L; Morrison, RS; Otis-Green, S; Pantilat, S; Portenoy, RK; Ritchie, C; Rocker, G; Wheeler, JL; Zafar, SY; Kutner, JS

Published Date

  • December 2010

Published In

Volume / Issue

  • 13 / 12

Start / End Page

  • 1407 - 1413

PubMed ID

  • 21105763

Pubmed Central ID

  • 21105763

Electronic International Standard Serial Number (EISSN)

  • 1557-7740

Digital Object Identifier (DOI)

  • 10.1089/jpm.2010.0261

Language

  • eng

Conference Location

  • United States