Management of gastrointestinal symptoms in advanced cancer patients: the rapid learning cancer clinic model.


Journal Article (Review)

PURPOSE OF REVIEW: Gastrointestinal symptoms are prevalent, often persistent, and detrimental to patients' quality of life. This review discusses evaluation of gastrointestinal symptoms as patient-reported outcomes (PROs) and presents an information technology-based system for symptom monitoring and management. The electronic PRO (ePRO) system is then placed within the larger context of rapid learning healthcare, a concept currently under development in which data obtained through both research and clinical care continuously build large datasets for analysis, seed future research, fuel expansion of the evidence base, and support clinical decision-making. RECENT FINDINGS: PROs are increasingly recognized as valid measures of symptoms, functional status, and quality of life. They have demonstrated prognostic significance and are being developed as a component of toxicity reporting in clinical trials. Recent studies have validated an information technology-based approach for collecting ePROs in routine clinical care. The system is feasible and acceptable; electronic and paper-based data, collected on validated assessment instruments, are equivalent; ePRO collection supports real-time symptom monitoring and management. The ePRO system represents a first step toward implementing rapid learning healthcare at the clinic level. SUMMARY: ePROs provide a rich source of information to support monitoring and clinical management of troubling symptoms such as gastrointestinal complaints.

Full Text

Duke Authors

Cited Authors

  • Abernethy, AP; Wheeler, JL; Zafar, SY

Published Date

  • March 2010

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 36 - 45

PubMed ID

  • 19952928

Pubmed Central ID

  • 19952928

Electronic International Standard Serial Number (EISSN)

  • 1751-4266

Digital Object Identifier (DOI)

  • 10.1097/SPC.0b013e32833575fd


  • eng

Conference Location

  • United States