Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury.

Journal Article (Clinical Trial;Journal Article)

Electrical activation of an excitatory reflex between sensory fibers in the pudendal nerve and the bladder has been demonstrated in cats and is a potential means of restoring micturition function in persons with spinal cord injury. We investigated the clinical feasibility of activating this reflex to restore bladder function in persons with spinal cord injury by using intraurethral electrical stimulation to activate pudendal sensory fibers innervating the urethra. Excitatory bladder responses (contractions) were evoked by trains of electrical pulses applied to either the proximal (29.7 +/- 11.6 cmH2O) or distal (30.2 +/- 11.6 cmH2O) segment of the urethra. The results indicate that an excitatory reflex between pudendal nerve afferents and the bladder exists in humans with spinal injury and may provide a substrate for restoring micturition function.

Full Text

Duke Authors

Cited Authors

  • Yoo, PB; Horvath, EE; Amundsen, CL; Webster, GD; Grill, WM

Published Date

  • 2009

Published In

  • Annu Int Conf Ieee Eng Med Biol Soc

Volume / Issue

  • 2009 /

Start / End Page

  • 6781 - 6784

PubMed ID

  • 19964708

Pubmed Central ID

  • PMC3662296

International Standard Serial Number (ISSN)

  • 2375-7477

Digital Object Identifier (DOI)

  • 10.1109/IEMBS.2009.5333982


  • eng

Conference Location

  • United States