The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features.

Journal Article (Journal Article)

In a series of 177 breast carcinomas, we found that the Oncotype DX Recurrence Score (RS) was correlated with six pathobiologic features: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status, and the three components of the Nottingham tumor grade. The RS also correlated with a composite index (the Breast Cancer Prognostic Score or BCPS) comprising the same six parameters. Categorical concordance was 56% and 66% using conventional and TAILORx cutoffs, respectively. Our data show that a composite prognostic index can be constructed from routinely reported breast tumor features that captures much of the information provided by the Oncotype assay at no added cost.

Full Text

Duke Authors

Cited Authors

  • Geradts, J; Bean, SM; Bentley, RC; Barry, WT

Published Date

  • November 2010

Published In

Volume / Issue

  • 28 / 9

Start / End Page

  • 969 - 977

PubMed ID

  • 20873988

Electronic International Standard Serial Number (EISSN)

  • 1532-4192

Digital Object Identifier (DOI)

  • 10.3109/07357907.2010.512600


  • eng

Conference Location

  • England