The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features.
Journal Article
In a series of 177 breast carcinomas, we found that the Oncotype DX Recurrence Score (RS) was correlated with six pathobiologic features: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status, and the three components of the Nottingham tumor grade. The RS also correlated with a composite index (the Breast Cancer Prognostic Score or BCPS) comprising the same six parameters. Categorical concordance was 56% and 66% using conventional and TAILORx cutoffs, respectively. Our data show that a composite prognostic index can be constructed from routinely reported breast tumor features that captures much of the information provided by the Oncotype assay at no added cost.
Full Text
Duke Authors
Cited Authors
- Geradts, J; Bean, SM; Bentley, RC; Barry, WT
Published Date
- November 2010
Published In
Volume / Issue
- 28 / 9
Start / End Page
- 969 - 977
PubMed ID
- 20873988
Pubmed Central ID
- 20873988
Electronic International Standard Serial Number (EISSN)
- 1532-4192
Digital Object Identifier (DOI)
- 10.3109/07357907.2010.512600
Language
- eng
Conference Location
- England