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Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions.

Publication ,  Journal Article
Bean, SM; Baker, A; Eloubeidi, M; Eltoum, I; Jhala, N; Crowe, R; Jhala, D; Chhieng, DC
Published in: Cancer Cytopathol
February 25, 2011

BACKGROUND: The role of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the evaluation of spindle cell and mesenchymal lesions is unclear. This study reviews the use of EUS-FNA in diagnosing intrathoracic and intra-abdominal spindle and mesenchymal cell lesions at an academic institution. METHODS: All EUS-FNA specimens with a significant spindle or mesenchymal cell component were retrieved. Follow-up was comprised of clinical correlation, chart review, or evaluation of subsequent tissue specimens, including FNAs, biopsies, and/or surgical resections. Lesions were categorized as either inflammatory/reactive or neoplastic. RESULTS: Forty-four EUS-FNA specimens were retrieved from 39 patients (21 men and 18 women with a median age of 61 years [range, 20-88 years]). Anatomic sites included 19 lymph node specimens, 15 gastrointestinal tract specimens, 7 pancreatic specimens, and 4 other anatomic site specimens. Twenty-two cases were inflammatory/reactive lesions, including 17 granulomatous lesions and 5 cases of chronic pancreatitis. Twenty-two cases were neoplastic, including 14 gastrointestinal stromal tumors, 2 smooth muscle tumors, 2 sarcomatoid carcinomas, 2 melanomas, 1 sarcoma, and 1 solitary fibrous tumor. A specific cytologic diagnosis was rendered in 30 cases (81%). Immunocytochemistry was performed on 21 neoplastic cases and contributed to the differential diagnosis in 18 cases. No false-positive findings were encountered. Three false-negative results were identified and were attributed to sampling error. CONCLUSIONS: Spindle cell neoplasms are rarely encountered on EUS-FNA. The differential diagnosis encompasses a wide variety of benign and neoplastic entities. Correlation of cytomorphology and ancillary studies yields a high diagnostic accuracy of spindle cell and mesenchymal lesions on EUS-FNA.

Duke Scholars

Published In

Cancer Cytopathol

DOI

ISSN

1934-662X

Publication Date

February 25, 2011

Volume

119

Issue

1

Start / End Page

37 / 48

Location

United States

Related Subject Headings

  • Young Adult
  • Sarcoma
  • Prognosis
  • Pancreatic Neoplasms
  • Middle Aged
  • Melanoma
  • Male
  • Lymph Nodes
  • Humans
  • Gastrointestinal Stromal Tumors
 

Citation

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Bean, S. M., Baker, A., Eloubeidi, M., Eltoum, I., Jhala, N., Crowe, R., … Chhieng, D. C. (2011). Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions. Cancer Cytopathol, 119(1), 37–48. https://doi.org/10.1002/cncy.20120
Bean, Sarah M., Allyson Baker, Mohamad Eloubeidi, Isam Eltoum, Nirag Jhala, Ralph Crowe, Darshana Jhala, and David C. Chhieng. “Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions.Cancer Cytopathol 119, no. 1 (February 25, 2011): 37–48. https://doi.org/10.1002/cncy.20120.
Bean SM, Baker A, Eloubeidi M, Eltoum I, Jhala N, Crowe R, et al. Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions. Cancer Cytopathol. 2011 Feb 25;119(1):37–48.
Bean, Sarah M., et al. “Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions.Cancer Cytopathol, vol. 119, no. 1, Feb. 2011, pp. 37–48. Pubmed, doi:10.1002/cncy.20120.
Bean SM, Baker A, Eloubeidi M, Eltoum I, Jhala N, Crowe R, Jhala D, Chhieng DC. Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions. Cancer Cytopathol. 2011 Feb 25;119(1):37–48.
Journal cover image

Published In

Cancer Cytopathol

DOI

ISSN

1934-662X

Publication Date

February 25, 2011

Volume

119

Issue

1

Start / End Page

37 / 48

Location

United States

Related Subject Headings

  • Young Adult
  • Sarcoma
  • Prognosis
  • Pancreatic Neoplasms
  • Middle Aged
  • Melanoma
  • Male
  • Lymph Nodes
  • Humans
  • Gastrointestinal Stromal Tumors