A historical perspective on the discovery of adenyl purines.


Journal Article

In 1929, Drury and Szent-Gyorgyi described the effects of a simple extract of heart muscle and other tissues on the mammalian heart. This extract was identified as adenylic acid and found to have profound effects on the cardiovascular system. The discovery and identification of adenyl purines and their effects on the cardiovascular system has now extended to other biological functions such as neurotransmission, neuromodulation, and endocrine/exocrine secretory functions and beyond. This review examines the history of the discovery and identification of the many roles played by adenyl purines in regulation of physiological homeostasis.

Full Text

Duke Authors

Cited Authors

  • Cheek, DJ; McHugh, JM; Blood-Siegfried, J; McFetridge, JF; Turner, BS

Published Date

  • April 2000

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 265 - 275

PubMed ID

  • 11232205

Pubmed Central ID

  • 11232205

Electronic International Standard Serial Number (EISSN)

  • 1552-4175

International Standard Serial Number (ISSN)

  • 1099-8004

Digital Object Identifier (DOI)

  • 10.1177/109980040000100403


  • eng