76-space analysis of grey matter diffusivity: methods and applications.


Journal Article

Diffusion Weighted Imaging (DWI) and Diffusion Tensor Imaging (DTI) are widely used in the study and diagnosis of neurological diseases involving the White Matter (WM). However, many neurological and neurodegenerative diseases (e.g., Alzheimer's disease and Creutzfeldt-Jakob disease) are generally considered to involve the Grey Matter (GM). Investigation of GM diffusivity of normal aging and pathological brains has both scientific significance and clinical applications. Most of previous research reports on quantification of GM diffusivity were based on the manually labeled Region of Interests (ROI) analysis of specific neuroanatomic regions. The well-known drawbacks of ROI analysis include inter-rater variations, irreproducible results, tediousness, and requirement of a priori definition of interested regions. In this paper, we present a new framework of automated 76-space analysis of GM diffusivity using DWI/DTI. The framework will be evaluated using clinical data, and applied for study of normal brain, Creutzfeldt-Jakob disease and Schizophrenia.

Full Text

Duke Authors

Cited Authors

  • Liu, T; Young, G; Huang, L; Chen, N-K; Wong, STC

Published Date

  • 2005

Published In

  • Med Image Comput Comput Assist Interv

Volume / Issue

  • 8 / Pt 1

Start / End Page

  • 148 - 155

PubMed ID

  • 16685840

Pubmed Central ID

  • 16685840

Digital Object Identifier (DOI)

  • 10.1007/11566465_19


  • eng

Conference Location

  • Germany